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Western blot analysis of TIP49b on HeLa lysate. Lane 1: 1:500, lane 1: 1:1000, lane 3: 1:2000 dilution of TIP49b.
MDCK
BD Transduction Laboratories™ Purified Mouse Anti-TIP49b
BD Transduction Laboratories™ Purified Mouse Anti-TIP49b
Regulatory Statusの凡例
Any use of products other than the permitted use without the express written authorization of Becton, Dickinson and Company is strictly prohibited.
Preparation and Storage
Product Notices
- Since applications vary, each investigator should titrate the reagent to obtain optimal results.
- Please refer to www.bdbiosciences.com/us/s/resources for technical protocols.
- Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
- Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Processes involving DNA transcription, replication and repair are necessary in maintaining normal cell function. For each of these processes, the double stranded NA must first be unwound. This is achieved in an ATP-dependent manner by enzymes termed DNA helicases. Reptin52/TIP49b is a DNA helicase that directly interacts with Pontin52/TIP49a. Reptin52/TIP49b and Pontin52/TIP49a belong to a family of highly conserved proteins that share homology with the bacterial protein RuvB, a helicase involved in double-strand break repair and homologous recombination. Both are TATA binding protein (TBP) interacting proteins that bind to β-Catenin and are among the 12 polypeptides that comprise the INO80 chromatin-remodeling complex. It has also been demonstrated that Reptin52/TIP49b and Pontin52/TIP49a can be found in a complex with the proto- ncogene c-myc. Reptin52/TIP49b and Pontin52/TIP49a have antagonistic roles as Reptin/TIP49b represses gene activation mediated by β-Catenin and c-myc, whereas Pontin52/TIP49a stimulates gene activation. Thus, Reptin52/TIP49b and Pontin52/TIP49a are transcriptional co-factors that work together to help control multiple pathways.
Development References (3)
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Bauer A, Chauvet S, Huber O. Pontin52 and reptin52 function as antagonistic regulators of beta-catenin signalling activity. EMBO J. 2000; 19(22):6121-6130. (Biology). View Reference
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Cho SG, Bhoumik A, Broday L, Ivanov V, Rosenstein B, Ronai Z. TIP49b, a regulator of activating transcription factor 2 response to stress and DNA damage. Mol Cell Biol. 2001; 21(24):8398-8413. (Biology). View Reference
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Kanemaki M, Kurokawa Y, Matsu-ura T. TIP49b, a new RuvB-like DNA helicase, is included in a complex together with another RuvB-like DNA helicase, TIP49a. J Biol Chem. 1999; 274(32):22437-22444. (Biology). View Reference
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