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Single-Cell Genomic Approaches for Developing the Next Generation of Immunotherapies
In recent times, developments in genomics, proteomics and single-cell technologies, coupled with advances in allied areas like computing and antibody engineering have enabled significant progress in drug development.
A New 16-Color Flow Cytometry Panel Protocol for the Functional Phenotyping of Circulating Human Cytotoxic T Cells and NK Cells
Building a panel for the intracellular staining of immune cells could pose several challenges.
Early Life Imprinting and Immune System Responses to Bifidobacteria Colonization
There is mounting evidence to suggest that during the first three months of life the infant gut microbiome is crucial for immune development.
A Method to Study Tissue Microenvironments at Single-Cell Resolution
Spatial transcriptomics is a rapidly evolving field aiming to capture transcriptomic features and spatial relationships of cells within tissues.
An Optimized Multicolor Immunophenotyping Panel to Profile NK Cells from Tumor Tissue
Natural killer (NK) cells have been a focus in immuno-oncology for decades, largely due to their ability to destroy tumor cells through spontaneous cytotoxicity as well as their production of cytokines and chemokines that can help recruit additional immune cells.
An Optimized 50-Color Flow Cytometry Panel for Analysis of T Cells and Dendritic Cells
Immune cell analysis at the periphery and at the tissue level has provided valuable insights into our understanding of how immune cells differentiate and what roles they play, as well as how they function in various diseases.
A High-Throughput Sample Processing Pipeline with a 28-Color Flow Cytometry Panel for Large Immunophenotyping Studies
The complexity of the immune system entails the simultaneous analysis of several parameters to gather meaningful insights.
A Novel Multiplex Flow Proxy Assay for the Simultaneous Measurement of Multiple Biomarkers
Combining the analysis of protein biomarkers to genome-wide expression profiling at the single-cell level provides deeper scientific insights than previously possible.
New Strategy for Phenotyping Human Dendritic Cells and Monocyte Cells
Recent technological developments in single-cell analysis have significantly advanced our understanding of the subset heterogeneity of antigen-presenting cells.
Antigen-specific B cells and chronic infection: The OMIP panel
Originating in the bone marrow, antigen-specific B cells are critical in infection prevention and control through antibody production, professional antigen presentation and cytokine secretion.
Immunotyping of Natural Killer (NK) Cells in COVID-19 Patients Using High-Parameter Flow Cytometry
SARS-CoV-2 infection elicits a spectrum of immune responses, activating both the innate and adaptive immune systems. Whether these immune responses are targeted and controlled or misdirected and uncontrolled could determine the outcome of the disease.
High-Parameter Flow Cytometry for Deep Immune Profiling of COVID-19 Patients
The SARS-CoV-2 virus infection presents a range of clinical manifestations, ranging from mild or no symptoms to moderate to severe respiratory illnesses, such as ARDS (acute respiratory-distress syndrome) and multiorgan failure, to death.