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The site is undergoing maintenance. Some pieces of functionality, including sign-in, may be impacted. Ordering can continue through fax and phone.
Explore multiple clones against CD38 available for ASR, RUO, and RUO (GMP) use. These antibodies can be used for applications such as flow cytometry, Western blot and Cite-seq against Mouse, Rat and Human targets. Our anti-CD38 antibodies were developed in Mouse and Rat and have Rat IgG2a κ, and Mouse IgG1 κ isotypes. Our CD38-specific antibodies have been used in over 500 articles in peer-reviewed journals. Review over 50 figures from product development to select the best reagents for your needs.
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Description: The protein encoded by this gene is a non-lineage-restricted, type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5'-diphosphate-ribose, an intracellular calcium ion mobilizing messenger. The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein. This protein has an N-terminal cytoplasmic tail, a single membrane-spanning domain, and a C-terminal extracellular region with four N-glycosylation sites. Crystal structure analysis demonstrates that the functional molecule is a dimer, with the central portion containing the catalytic site. It is used as a prognostic marker for patients with chronic lymphocytic leukemia. Alternative splicing results in multiple transcript variants.
Description: This gene encodes a non-lineage-restricted, type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5'-diphosphate-ribose, an intracellular calcium ion mobilizing messenger. The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein. This protein has an N-terminal cytoplasmic tail, a single membrane-spanning domain, and a C-terminal extracellular region with four N-glycosylation sites. Knockout mice deficient for this gene display altered humoral immune responses. In addition, knockout mice exhibit higher locomotor activity and defects in nurturing and social behaviors.
Function: Synthesizes cyclic ADP-ribose (cADPR), a second messenger for glucose-induced insulin secretion. Synthesizes the Ca2+ mobilizer nicotinate-adenine dinucleotide phosphate, NAADP+, from 2'-phospho-cADPR and nicotinic acid, as well as from NADP+ and nicotinic acid. At both pH 5.0 and pH 7.4 preferentially transforms 2'-phospho-cADPR into NAADP+, while preferentially cleaving NADP+ to cADPR and ADPRP rather than into NADDP+ . Has cADPR hydrolase activity .
Molecular Function: Hydrolase, Receptor, Transferase
Subcellular location: Cell surface, membrane
kDa: 34
Function: Synthesizes the second messengers cyclic ADP-ribose (cADPR) and nicotinate-adenine dinucleotide phosphate (NAADP), the former a second messenger for glucose-induced insulin secretion, the latter a Ca2+ mobilizer. Also has cADPR hydrolase activity
Molecular Function: Hydrolase, Transferase
Subcellular location: Membrane
Protein Family: ADP-ribosyl cyclase family
kDa: 34
I-19, ADPRC 1, Cd38-rs12'-phospho-ADP-ribosyl cyclase, 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase, 2'-phospho-cyclic-ADP-ribose transferase, ADP-ribosyl cyclase 1 (ADPRC 1), Cyclic ADP-ribose hydrolase 1 (cADPR hydrolase 1), NIM-R5 antigen, ADPRC1, cADPR1, ADPRC 12'-phospho-ADP-ribosyl cyclase, 2, T1
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
