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IL-4 Antibodies

Explore over 5 clones against IL-4 available for RUO, and RUO (GMP) use. These antibodies can be used for applications such as ELISA, ELISA capture, ELISA detection, against Mouse, Rat and Human targets. Our IL-4 antibodies were developed in Mouse and Rat and have Rat IgG2b, Rat IgG1 κ, and Mouse IgG1 κ isotypes. Our IL-4 antibodies have been used in over 500 articles in peer-reviewed journals. Review over 30 figures from product development to select the best reagents for your needs.


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Entrez Gene

Human Gene ID: 3565

Description: The protein encoded by this gene is a non-lineage-restricted, type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5'-diphosphate-ribose, an intracellular calcium ion mobilizing messenger. The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein. This protein has an N-terminal cytoplasmic tail, a single membrane-spanning domain, and a C-terminal extracellular region with four N-glycosylation sites. Crystal structure analysis demonstrates that the functional molecule is a dimer, with the central portion containing the catalytic site. It is used as a prognostic marker for patients with chronic lymphocytic leukemia. Alternative splicing results in multiple transcript variants.

 

Mouse Gene ID: 16189

Description: Enables cytokine activity. Involved in several processes, including innate immune response in mucosa; negative regulation of white fat cell proliferation; and regulation of gene expression. Acts upstream of or within several processes, including T-helper cell differentiation; positive regulation of macromolecule metabolic process; and regulation of leukocyte activation. Located in external side of plasma membrane and extracellular space. Is expressed in several structures, including brain; colon; hemolymphoid system; liver; and placenta. Used to study Sjogren's syndrome; atopic dermatitis; and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including asthma (multiple); autoimmune disease (multiple); hepatitis B; hepatitis C; and pancreatic cancer (multiple). Orthologous to human IL4 (interleukin 4). 


Rat Gene ID: 287287

Description: Predicted to enable cytokine activity. Involved in several processes, including positive regulation of biosynthetic process; positive regulation of leukocyte migration; and regulation of defense response. Located in extracellular space. Used to study anti-basement membrane glomerulonephritis; autoimmune thyroiditis; and pelvic inflammatory disease. Biomarker of several diseases, including cerebrovascular disease (multiple); interstitial lung disease (multiple); irritant dermatitis; primary biliary cholangitis; and rhinitis (multiple). Human ortholog(s) of this gene implicated in several diseases, including asthma (multiple); autoimmune disease (multiple); hepatitis B; hepatitis C; and pancreatic cancer (multiple). Orthologous to human IL4 (interleukin 4).


UniProt

Human UniProt ID: P05112 

Function: Cytokine secreted primarily by mast cells, T-cells, eosinophils, and basophils that plays a role in regulating antibody production, hematopoiesis and inflammation, and the development of effector T-cell responses. Induces the expression of class II MHC molecules on resting B-cells. Enhances both secretion and cell surface expression of IgE and IgG1. Regulates also the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4. In addition, plays a critical role in higher functions of the normal brain, such as memory and learning (By similarity). Upon binding to IL4, IL4R receptor dimerizes either with the common IL2R gamma chain/IL2RG to produce the type 1 signaling complex, located mainly on hematopoietic cells, or with the IL13RA1 to produce the type 2 complex, which is expressed also on nonhematopoietic cells. Engagement of both types of receptors initiates JAK3 and to a lower extend JAK1 phosphorylation leading to activation of the signal transducer and activator of transcription 6/STAT6.

Molecular Function: Cytokine, Growth factor, Subcellular location: Cell surface, membrane

Subcellular Function: Secreted

Protein Family: IL-4/IL-13 family

kDa: 17


Mouse UniProt ID: P07750

Function: Cytokine secreted primarily by mast cells, T-cells, eosinophils, and basophils that plays a role in regulating antibody production, hematopoiesis and inflammation, and the development of effector T-cell responses. Induces the expression of class II MHC molecules on resting B-cells. Enhances both secretion and cell surface expression of IgE and IgG1. Regulates also the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes (By similarity). Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4. In addition, plays a critical role in higher functions of the normal brain, such as memory and learning. Upon binding to IL4, IL4R receptor dimerizes either with the common IL2R gamma chain/IL2RG to produce the type 1 signaling complex, located mainly on hematopoietic cells, or with the IL13RA1 to produce the type 2 complex, which is expressed also on nonhematopoietic cells. Engagement of both types of receptors initiates JAK3 and to a lower extend JAK1 phosphorylation leading to activation of the signal transducer and activator of transcription 6/STAT6.

Molecular Function: Cytokine, Growth factor

Subcellular location: Secreted

Protein Family: IL-4/IL-13 family

kDa: 16


Rat UniProt ID: P20096

Function: Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4

Molecular Function: Cytokine, Growth factor

Subcellular location: Secreted

Protein family: IL-4/IL-13 family.

kDa: 16


AKA

BSF1, BCGF1, BSF-1; BCGF-1B-cell stimulatory factor 1 (BSF-1), Binetrakin, Lymphocyte stimulatory factor 1, Pitrakinra, Il-4, BSF-1, B-cell IgG differentiation factor, B-cell growth factor 1, B-cell stimulatory factor 1 (BSF-1), IGG1 induction factor, B-cell growth factor 1, B-cell stimulatory factor 1 (BSF-1), Lymphocyte stimulatory factor 

IL-4 Antibody Products


554434|Purified Rat Anti-Mouse IL-4
クローン
11B11
サイズ
0.5 mg
キャンペーンステータス
RUO
クローン
11B11
サイズ
0.5 mg
キャンペーンステータス
RUO
567744|BB700 Rat Anti-Human IL-4
クローン
MP4-25D2
サイズ
100 Tests
キャンペーンステータス
RUO
クローン
MP4-25D2
サイズ
100 Tests
キャンペーンステータス
RUO
567745|BB700 Rat Anti-Human IL-4
クローン
MP4-25D2
サイズ
25 Tests
キャンペーンステータス
RUO
クローン
MP4-25D2
サイズ
25 Tests
キャンペーンステータス
RUO
569087|RB780 Rat Anti-Human IL-4
クローン
MP4-25D2
サイズ
100 Tests
キャンペーンステータス
RUO
クローン
MP4-25D2
サイズ
100 Tests
キャンペーンステータス
RUO
551084|Human IL-4 ELISPOT Set
クローン
サイズ
10 Plate(s)
キャンペーンステータス
RUO
クローン
サイズ
10 Plate(s)
キャンペーンステータス
RUO
564007|BV605 Rat Anti-Mouse IL-4
クローン
11B11
サイズ
50 µg
キャンペーンステータス
RUO
クローン
11B11
サイズ
50 µg
キャンペーンステータス
RUO
564005|BV711 Rat Anti-Mouse IL-4
クローン
11B11
サイズ
50 µg
キャンペーンステータス
RUO
クローン
11B11
サイズ
50 µg
キャンペーンステータス
RUO
554484|FITC Rat Anti-Human IL-4
クローン
MP4-25D2
サイズ
0.1 mg
キャンペーンステータス
RUO
クローン
MP4-25D2
サイズ
0.1 mg
キャンペーンステータス
RUO
554485|PE Rat Anti-Human IL-4
クローン
MP4-25D2
サイズ
0.1 mg
キャンペーンステータス
RUO
クローン
MP4-25D2
サイズ
0.1 mg
キャンペーンステータス
RUO
554486|APC Rat Anti-Human IL-4
クローン
MP4-25D2
サイズ
0.1 mg
キャンペーンステータス
RUO
クローン
MP4-25D2
サイズ
0.1 mg
キャンペーンステータス
RUO
558462|Human IL-4 Standard
クローン
サイズ
キャンペーンステータス
RUO
クローン
サイズ
キャンペーンステータス
RUO

  

  

For Research Use Only. Not for use in diagnostic or therapeutic procedures.