Entrez Gene

Human Gene ID: 201633

Description: This gene encodes a member of the PVR (poliovirus receptor) family of immunoglobin proteins. The product of this gene is expressed on several classes of T cells including follicular B helper T cells (TFH). The protein has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses.

Mouse Gene ID: 100043314

Description: Enables signaling receptor binding activity. Acts upstream of or within negative regulation of T cell activation. Predicted to be active in cell surface. Orthologous to human TIGIT (T cell immunoreceptor with Ig and ITIM domains).

kDa: 14

UniProt

Human UniProt ID: Q495A1

Function: Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.

Subcellular location: Cell membrane

kDa: 26

Mouse UniProt ID: P86176

Function: Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.

Subcellular location: Cell membrane

kDa: 30
 

AKA

VSIG9; VSTM3; WUCAMV-set and immunoglobulin domain-containing protein 9; V-set and transmembrane domain-containing protein 3