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      Purified Rat Anti-Human CD201
      Purified Rat Anti-Human CD201
      Flow cytometric analysis of CD201 expression on ECV304 cell line. ECV304 cells were stained with either Purified Rat Anti-Human CD201 (Cat. No. 552500; solid line histogram) or Purified Rat IgG1, κ Isotype Control (Cat. No. 555839; dashed line histogram), followed by FITC Goat Anti-Rat Ig (Cat. No. 554016). Fluorescent histograms were derived from gated events with the side and forward light-scattering characteristics of viable cells.
      Purified Rat Anti-Human CD201
      Flow cytometric analysis of CD201 expression on ECV304 cell line. ECV304 cells were stained with either Purified Rat Anti-Human CD201 (Cat. No. 552500; solid line histogram) or Purified Rat IgG1, κ Isotype Control (Cat. No. 555839; dashed line histogram), followed by FITC Goat Anti-Rat Ig (Cat. No. 554016). Fluorescent histograms were derived from gated events with the side and forward light-scattering characteristics of viable cells.
      製品詳細
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      BD Pharmingen™
      EPCR; Activated protein C receptor; APC receptor; PROCR; centrocyclin
      Human (QC Testing)
      Rat WI, also known as Wistar (outbred) IgG1, κ
      EPCR-positive RE-1 Cells
      Flow cytometry (Routinely Tested)
      0.5 mg/ml
      VII 70424
      AB_394402
      Aqueous buffered solution containing ≤0.09% sodium azide.
      RUO


      Product Notices

      1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
      2. An isotype control should be used at the same concentration as the antibody of interest.
      3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
      4. Sodium azide is a reversible inhibitor of oxidative metabolism; therefore, antibody preparations containing this preservative agent must not be used in cell cultures nor injected into animals. Sodium azide may be removed by washing stained cells or plate-bound antibody or dialyzing soluble antibody in sodium azide-free buffer. Since endotoxin may also affect the results of functional studies, we recommend the NA/LE (No Azide/Low Endotoxin) antibody format, if available, for in vitro and in vivo use.
      5. Please refer to www.bdbiosciences.com/us/s/resources for technical protocols.
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      552500 Rev. 4
      抗体の詳細
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      RCR-252

      The RCR-252 monoclonal antibody specifically binds to the endothelial cell protein C receptor (EPCR), which is also known as CD201. CD201 is a 25 kDa, type I transmembrane glycoprotein, expressed on endothelial cells in arteries, veins and capillaries. CD201 binds activated protein C, a serine protease that is involved in regulating blood coagulation. EPCR is reportedly expressed on several malignant cell lines. Malignant cell lines that express EPCR can show significant levels of protein C activation and this activation can be inhibited by anti-EPCR antibody

      552500 Rev. 4
      フォーマットの詳細
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      Purified
      Tissue culture supernatant is purified by either protein A/G or affinity purification methods. Both methods yield antibody in solution that is free of most other soluble proteins, lipids, etc. This format provides pure antibody that is suitable for a number of downstream applications including: secondary labeling for flow cytometry or microscopy, ELISA, Western blot, etc.
      Purified
      552500 Rev.4
      引用＆参考文献
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      Development References (4)

      1. Biguzzi E, Merati G, Liaw PC, et al. A 23bp insertion in the endothelial protein C receptor (EPCR) gene impairs EPCR function. Thromb Haemost. 2001; 86(4):945-948. (Biology). View Reference
      2. Mason D. David Mason .. et al., ed. Leucocyte typing VII : white cell differentiation antigens : proceedings of the Seventh International Workshop and Conference held in Harrogate, United Kingdom. Oxford: Oxford University Press; 2002.
      3. Sturn DH, Kaneider NC, Feistritzer C, Djanani A, Fukudome K, Wiedermann CJ. Expression and function of the endothelial protein C receptor in human neutrophils. Blood. 2003; 102(4):1499-1505. (Immunogen). View Reference
      4. Tsuneyoshi N, Fukudome K, Horiguchi S, et al. Expression and anticoagulant function of the endothelial cell protein C receptor (EPCR) in cancer cell lines. Thromb Haemost. 2001; 85(2):356-361. (Biology). View Reference
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      552500 Rev. 4

      Please refer to Support Documents for Quality Certificates


      Global - Refer to manufacturer's instructions for use and related User Manuals and Technical data sheets before using this products as described


      Comparisons, where applicable, are made against older BD Technology, manual methods or are general performance claims.  Comparisons are not made against non-BD technologies, unless otherwise noted.

      For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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