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Flow cytometric analysis using BD OptiBuild™ BV421 Rat Anti-Mouse CD132 (common γ chain) antibody (Cat. No. 740039; solid line histogram) on live C57BL/6 mouse splenocytes, with corresponding Ig Isotype Control (dotted line histogram). Flow cytometry was performed using a BD™ LSR II Flow Cytometer System.
Flow cytometric analysis using BD OptiBuild™ BV421 Rat Anti-Mouse CD132 (common γ chain) antibody (Cat. No. 740039; solid line histogram) on live C57BL/6 mouse splenocytes, with corresponding Ig Isotype Control (dotted line histogram). Flow cytometry was performed using a BD™ LSR II Flow Cytometer System.
Flow cytometric analysis using BD OptiBuild™ BV421 Rat Anti-Mouse CD132 (common γ chain) antibody (Cat. No. 740039; solid line histogram) on live C57BL/6 mouse splenocytes, with corresponding Ig Isotype Control (dotted line histogram). Flow cytometry was performed using a BD™ LSR II Flow Cytometer System.
Flow cytometric analysis using BD OptiBuild™ BV421 Rat Anti-Mouse CD132 (common γ chain) antibody (Cat. No. 740039; solid line histogram) on live C57BL/6 mouse splenocytes, with corresponding Ig Isotype Control (dotted line histogram). Flow cytometry was performed using a BD™ LSR II Flow Cytometer System.
For optimal and reproducible results, BD Horizon Brilliant Stain Buffer should be used anytime two or more BD Horizon Brilliant dyes (including BD OptiBuild Brilliant reagents) are used in the same experiment. Fluorescent dye interactions may cause staining artifacts which may affect data interpretation. The BD Horizon Brilliant Stain Buffer was designed to minimize these interactions. More information can be found in the Technical Data Sheet of the BD Horizon Brilliant Stain Buffer (Cat. No. 563794).
The TUGm2 monoclonal antibody specifically binds to CD132, which is also known as, the common γ subunit (γc). The γc chain subunit is shared by the IL-2, IL-4, IL-7, IL-9, and IL-15 receptor complexes. The γc receptor is expressed constitutively at low levels by most lymphocytes, myeloid cells, embryonic thymocytes, and lymphoid cell lines. The γc receptor is a 75-80 kD transmembrane glycoprotein which mediates signal transducing activities of cytokine receptor complexes with which it is associated. TUGm2 antibody can significantly block the binding of and proliferative response to IL-4 by CTLL-2 cells. It can also inhibit binding to high-affinity IL-2 receptors expressed by CTLL-2 cells. By itself, the TUGm2 antibody reportedly fails to significantly inhibit CTLL-2 proliferative responses to IL-2. However, when added along with TM-β1 (Cat. No. 553359), specific for the mouse IL-2Rβ chain, TUGm2 was shown to synergistically reduce IL-2-driven CTLL-2 proliferative responses. TUGm2 can reduce the IL-7-induced proliferation of Con A-activated mouse splenocytes and the IL-7 responsive pre-B cell line, IxN/2b.
The antibody was conjugated to BD Horizon™ BV421 which is part of the BD Horizon Brilliant™ Violet family of dyes. With an Ex Max of 407-nm and Em Max at 421-nm, BD Horizon BV421 can be excited by the violet laser and detected in the standard Pacific Blue™ filter set (eg, 450/50-nm filter). BD Horizon BV421 conjugates are very bright, often exhibiting a 10 fold improvement in brightness compared to Pacific Blue conjugates.
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Comparisons, where applicable, are made against older BD Technology, manual methods or are general performance claims. Comparisons are not made against non-BD technologies, unless otherwise noted.
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
