BD Pharmingen™ Alexa Fluor® 647 Mouse anti-Human CD192 (CCR2)
クローン 48607 (RUO)
Preparation and Storage
Product Notices
- This reagent has been pre-diluted for use at the recommended Volume per Test. We typically use 1 × 10^6 cells in a 100-µl experimental sample (a test).
- Please refer to www.bdbiosciences.com/us/s/resources for technical protocols.
- The Alexa Fluor®, Pacific Blue™, and Cascade Blue® dye antibody conjugates in this product are sold under license from Molecular Probes, Inc. for research use only, excluding use in combination with microarrays, or as analyte specific reagents. The Alexa Fluor® dyes (except for Alexa Fluor® 430), Pacific Blue™ dye, and Cascade Blue® dye are covered by pending and issued patents.
- Alexa Fluor® 647 fluorochrome emission is collected at the same instrument settings as for allophycocyanin (APC).
- Alexa Fluor® is a registered trademark of Molecular Probes, Inc., Eugene, OR.
- For fluorochrome spectra and suitable instrument settings, please refer to our Multicolor Flow Cytometry web page at www.bdbiosciences.com/colors.
- Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
- Source of all serum proteins is from USDA inspected abattoirs located in the United States.
The 48607 monoclonal antibody specifically binds to CD192 which is also known as, Chemokine C-C motif receptor 2 (CCR2), Monocyte chemoattractant protein 1 receptor (MCP-1 receptor/MCP-1-R), or CKR2. CD192 is a seven-transmembrane, G-protein-coupled receptor that is the specific receptor for Monocyte chemoattractant protein 1 (MCP-1/CCL2), MCP-2/CCL8, MCP-3/CCL7, and MCP-4/CCL13. CD192 is expressed on monocytes, dendritic cells, NK cells, basophils, and activated T cells and B cells. CD192 exists in two forms, CD192A and CD192B. The two forms are derived from alternatively spliced variants of a single gene and differ at the C-terminal end. CD192 plays an important role in inflammatory responses.
Development References (3)
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Charo IF, Myers SJ, Herman A, Franci C, Connolly AJ, Coughlin SR. Molecular cloning and functional expression of two monocyte chemoattractant protein 1 receptors reveals alternative splicing of the carboxyl-terminal tails. Proc Natl Acad Sci U S A. 1994; 91(7):2752-2756. (Biology). View Reference
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Wong LM, Myers SJ, Tsou CL, Gosling J, Arai H, Charo IF. Organization and Differential Expression of the Human Monocyte Chemoattractant Protein 1Receptor Gene. EVIDENCE FOR THE ROLE OF THE CARBOXYL-TERMINAL TAIL IN RECEPTOR TRAFFICKING . J Biol Chem. 1997; 272(2):1038-1045. (Biology). View Reference
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Yamagami S, Tokuda Y, Ishii K, Tanaka H, Endo N. cDNA cloning and functional expression of a human monocyte chemoattractant protein 1 receptor. Biochem Biophys Res Commun. 1994; 202(2):1156-1162. (Biology). View Reference
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For Research Use Only. Not for use in diagnostic or therapeutic procedures.