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The catenins (α, β, γ, δ, p120[ctn]) are cytoplasmic proteins that are related to the Drosophila Armadillo protein. Catenins may have dual roles since they are components of cell-cell adherens junctions and can translocate to the nucleus after stimulation of the Wingless (Wnt-1 homolog) signaling pathway. α-Catenin has two subtypes: αE-Catenin, which is expressed ubiquitously, and αN-Catenin, which is expressed in the nervous system. β-Catenin binds to the cytoplasmic tail of E-Cadherin at adherens junctions and has been implicated in Wnt-1 signaling. γ-Catenin is associated with desmoglein in desmosomes and is closely related to β-Catenin. p120[ctn] is related to both β- and γ-catenin and is a substrate of tyrosine kinases localized at adherens junctions. δ-catenin was identified by its ability to bind the Alzheimer's disease-related protein, presenilin-1. It is most closely related to p120[ctn] and the desmosomal protein, p0071. It contains 10 Armadillo (Arm) repeats, as compared to the 13 Arm repeats found in β-Catenin. δ-Catenin is expressed at high levels in the developing nervous system, where it may be involved in neuronal progenitor cell migration and dendrite development.
研发参考 (5)
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Ho C, Zhou J, Medina M. delta-catenin is a nervous system-specific adherens junction protein which undergoes dynamic relocalization during development. J Comp Neurol. 2000; 420(2):261-276. (Biology). 查看参考
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Izawa I, Nishizawa M, Ohtakara K, Inagaki M. Densin-180 interacts with delta-catenin/neural plakophilin-related armadillo repeat protein at synapses. J Biol Chem. 2002; 277(7):5345-5350. (Clone-specific: Immunofluorescence, Immunoprecipitation, Western blot). 查看参考
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Laura RP, Witt AS, Held HA. The Erbin PDZ domain binds with high affinity and specificity to the carboxyl termini of delta-catenin and ARVCF. J Biol Chem. 2002; 277(15):12906-12914. (Clone-specific: Immunofluorescence, Western blot). 查看参考
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Lu Q, Paredes M, Medina M. delta-catenin, an adhesive junction-associated protein which promotes cell scattering. J Cell Biol. 1999; 144(3):519-532. (Biology). 查看参考
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Zhou J, Liyanage U, Medina M. Presenilin 1 interaction in the brain with a novel member of the Armadillo family. Neuroreport. 1997; 8(8):2085-2090. (Biology). 查看参考
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