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- Since applications vary, each investigator should titrate the reagent to obtain optimal results.
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Reacts with von Willebrand Factor (vWF), a multimeric plasma glycoprotein synthesized by endothelial cells and megakaryocytes. In plasma, vWF circulates as multimers which range from dimers of about 500 kDa to multimers of 20000 kDa. It functions as a carrier for Factor VIII and is a mediator of initial platelet adhesion to subendothelium and platelet-platelet interaction. Platelets bind to vWF through the platelet GPIb/IX (CD42b/CD42a) and GPIIb/IIIa (CD41/CD61) complexes This antibody is effective in detecting vWF by ELISA, with no evidence of cross reactivity with fibronectin or fibrinogen.
研发参考 (2)
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Ginsburg D, Bockenstedt PL, Allen EA, et al. Fine mapping of monoclonal antibody epitopes on human von Willebrand factor using a recombinant peptide library. Thromb Haemost. 1991; 67(1):166-171. (Clone-specific: Immunohistochemistry). 查看参考
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Sadler JE. von Willebrand factor. J Biol Chem. 1991; 266(34):22777-22780. (Clone-specific: Immunohistochemistry). 查看参考
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