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      Purified Mouse Anti-ALDH
      ALDH_WB_5.png

      Western blot analysis of ALDH on A431 cell lysate. Lane 1: 1:500, lane 2: 1:1000, lane 3: 1:2000 dilution of anti-ALDH antibody.

      A84320_611195_image2.png

      Immunofluorescent staining of HepG2 cells with anti-ALDH.

      ALDH_WB_5.png A84320_611195_image2.png Blue-Cap-White-Label.jpg

      Western blot analysis of ALDH on A431 cell lysate. Lane 1: 1:500, lane 2: 1:1000, lane 3: 1:2000 dilution of anti-ALDH antibody.

      Immunofluorescent staining of HepG2 cells with anti-ALDH.

      商品详情
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      BD Transduction Laboratories™
      Human (QC Testing)
      Mouse IgG1
      Human ALDH1 aa. 7-128
      Western blot (Routinely Tested), Immunofluorescence (Tested During Development), Immunohistochemistry (Reported)
      55 kDa
      250 µg/ml
      AB_398729
      Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
      RUO


      商品通知

      1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
      2. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
      3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
      4. Please refer to www.bdbiosciences.com/us/s/resources for technical protocols.
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      611195 Rev. 3
      抗体详情
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      44/ALDH

      Aldehyde dehydrogenase (ALDH) is a ubiquitous enzyme located in nearly all mammalian tissues. It catalyzes the irreversible oxidation of a range of aliphatic and aromatic aldehydes to their corresponding carboxylic acids. There are multiple isoforms of ALDH which are subdivided into three classes. Class I includes the cytosolic isoforms. Class II includes the mitochondrial isoforms. Class III includes the microsomal, cytosolic tumor specific, and cytosolic dioxin-inducible forms. At least twelve human ALDH isoforms have been identified. Mutations of many of these proteins such as ALDH1, ALDH2, ALDH4, and ALDH10 have been implicated in multiple human metabolic disorders and clinical abnormalities. At the amino acid level, human ALDH isoforms exhibit a wide range of diversity (15% to about 80%). However, multiple protein regions have been highly conserved and are important for functional activities. A well-characterized member of the human ALDH family is ALDH1. It plays a major role in the biosynthesis of retinoic acid from retinol (vitamin A). Retinoic acid, the biologically active form of retinol, is a regulator of cellular proliferation, differentiation, and survival.

      611195 Rev. 3
      格式详情
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      Purified
      Tissue culture supernatant is purified by either protein A/G or affinity purification methods. Both methods yield antibody in solution that is free of most other soluble proteins, lipids, etc. This format provides pure antibody that is suitable for a number of downstream applications including: secondary labeling for flow cytometry or microscopy, ELISA, Western blot, etc.
      Purified
      611195 Rev.3
      报价单和参考
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      View product citations for antibody "611195" on CiteAb

      研发参考 (4)

      1. Greene WK, Bahn S, Masson N, Rabbitts TH. The T-cell oncogenic protein HOX11 activates Aldh1 expression in NIH 3T3 cells but represses its expression in mouse spleen development. Mol Cell Biol. 1998; 18(12):7030-7037. (Biology). 查看参考
      2. Kathmann EC, Lipsky JJ. Cloning of a cDNA encoding a constitutively expressed rat liver cytosolic aldehyde dehydrogenase. Biochim Biophys Acta. 1997; 236(2):527-531. (Biology). 查看参考
      3. Yoshida A, Rzhetsky A, Hsu LC, Chang C. Human aldehyde dehydrogenase gene family. J Biol Chem. 1998; 251(3):549-557. (Biology). 查看参考
      4. Zhou JH, Hanna EY, Roberts D, Weber RS, Bell D. ALDH1 immunohistochemical expression and its significance in salivary adenoid cystic carcinoma. Head & Neck. 2012; 35(4):575-578. (Clone-specific: Immunohistochemistry). 查看参考
      查看所有文件 (4) 查看更少内容
      611195 Rev. 3

      Please refer to Support Documents for Quality Certificates

       

      Global - Refer to manufacturer's instructions for use and related User Manuals and Technical data sheets before using this products as described

       

      Comparisons, where applicable, are made against older BD Technology, manual methods or are general performance claims.  Comparisons are not made against non-BD technologies, unless otherwise noted.

      For Research Use Only. Not for use in diagnostic or therapeutic procedures.