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      Purified Mouse Anti-LRP
      Purified Mouse Anti-LRP
      Western blot analysis of LRP on human endothelial lysate.  Lane 1: 1:1000, lane 2: 1:2000, lane 3: 1:4000 dilution of LRP.
      Purified Mouse Anti-LRP
      Immunofluorescence staining of Rabbit Kidney
      Purified Mouse Anti-LRP Purified Mouse Anti-LRP
      Western blot analysis of LRP on human endothelial lysate.  Lane 1: 1:1000, lane 2: 1:2000, lane 3: 1:4000 dilution of LRP.
      Immunofluorescence staining of Rabbit Kidney
      商品详情
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      BD Transduction Laboratories™
      Human (QC Testing), Dog, Rabbit, Cow (Tested in Development)
      Mouse IgG1
      Human LRP aa. 403-592
      Western blot (Routinely Tested), Immunofluorescence, Immunohistochemistry, Immunoprecipitation (Tested During Development)
      110 kDa
      250 µg/ml
      AB_397875
      Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
      RUO


      商品通知

      1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
      2. Please refer to www.bdbiosciences.com/us/s/resources for technical protocols.
      3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
      4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
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      610512 Rev. 1
      抗体详情
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      42/LRP

      Drugs that selectively attack dividing cells are often used in cancer therapy. However, small cell populations do not die, but develop resistance to a variety of toxic drugs. Multidrug resistance is achieved by gene amplification of specific membrane-bound transport ATPases that shuttle the drugs out of cells. Some multidrug-resistant cancer cells express a protein of 110 kDa named LRP (Lung Resistance-related Protein). LRP expression might be an indicator of prognosis after chemotherapy in acute myeloid leukemia and ovarian carcinoma. The LRP gene encodes a protein of 896 amino acids with significant homology to the major vault protein from Dictyostelium discoideum. Although ubiquitously expressed, LRP is most abundant in epithelial cells.

      610512 Rev. 1
      格式详情
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      Purified
      Tissue culture supernatant is purified by either protein A/G or affinity purification methods. Both methods yield antibody in solution that is free of most other soluble proteins, lipids, etc. This format provides pure antibody that is suitable for a number of downstream applications including: secondary labeling for flow cytometry or microscopy, ELISA, Western blot, etc.
      Purified
      610512 Rev.1
      报价单和参考
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      研发参考 (4)

      1. Kickhoefer VA, Rome LH. The sequence of a cDNA encoding the major vault protein from Rattus norvegicus. Gene. 1994; 151(1-2):257-260. (Biology). 查看参考
      2. List AF, Spier CS, Grogan TM. Overexpression of the major vault transporter protein lung-resistance protein predicts treatment outcome in acute myeloid leukemia. Blood. 1996; 87(6):2464-2469. (Biology). 查看参考
      3. Rybarova S, Batekova M, Hodorova I. Immunohistochemical detection of LRP protein in the normal human lung. Bratisl Lek Listy. 2002; 102(2):66-72. (Clone-specific: Immunohistochemistry). 查看参考
      4. Scheffer GL, Wijngaard PL, Flens MJ. The drug resistance-related protein LRP is the human major vault protein. Nat Med. 1995; 1(6):578-582. (Biology). 查看参考
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      610512 Rev. 1

      Please refer to Support Documents for Quality Certificates


      Global - Refer to manufacturer's instructions for use and related User Manuals and Technical data sheets before using this products as described


      Comparisons, where applicable, are made against older BD Technology, manual methods or are general performance claims.  Comparisons are not made against non-BD technologies, unless otherwise noted.

      For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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