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BD Pharmingen™ Purified NA/LE Anti-Human HER2 Trastuzumab Biosimilar
克隆 Trastuzumab.rMAb (also known as Trastuzumab Biosimilar)
(RUO)Inhibition of Human SK-BR-3 tumor cell proliferation by treatment with Trastuzumab Biosimilar.rMAb. Cells from the Human SK-BR-3 (Breast adenocarcinoma, ATCC® HTB-30™) cell line were treated with different doses of either Purified NA/LE Human IgG1, κ Isotype Control (Cat. No. 569605; Black Line) or Purified NA/LE Human Anti-Human ErbB2/HER-2 (CD340) Trastuzumab Biosimilar (Cat. No. 569599; Red Line) as shown with cell viability measured by an MTT Assay at OD 570 nm absorbance.
BD Pharmingen™ Purified NA/LE Anti-Human HER2 Trastuzumab Biosimilar
监管状态图例
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准备和存储
商品通知
- Please refer to www.bdbiosciences.com/us/s/resources for technical protocols.
- Since applications vary, each investigator should titrate the reagent to obtain optimal results.
- Please refer to http://regdocs.bd.com to access safety data sheets (SDS).
- An isotype control should be used at the same concentration as the antibody of interest.
- For U.S. patents that may apply, see bd.com/patents.
配套商品
The Trastuzumab.rMAb (also known as Trastuzumab Biosimilar.rMAb) is a research grade, chimeric recombinant human IgG1 kappa antibody that specifically recognizes the extracellular domain of Human Epidermal Growth Factor Receptor 2 (also known as HER2, HER-2, ErbB2, NEU, or CD340) similarly to the therapeutic Trastuzumab antibody. The Trastuzumab.rMAb uses the same variable region sequences as Trastuzumab, combined with constant region sequences derived from consensus sequences of human IgG1, kappa. Trastuzumab is a humanized therapeutic monoclonal antibody that was originally made by inserting the immunoglobulin (Ig) variable region sequences of the human HER-2-specific mouse monoclonal, 4D5. HER2 is a ~185 kDa type I transmembrane glycoprotein that is encoded by ERBB2 (erb-b2 receptor tyrosine kinase 2) which belongs to the ERBB family of receptor tyrosine kinases that includes EGFR (HER1), HER3, and HER4. Members of this receptor subfamily mediate the proliferation and differentiation of normal cells. Although HER2 has no identified direct-binding ligand, it forms signaling heterodimeric receptors with other ligand-bound ERBB family members. HER2 activates intracellular signaling pathways including MAPK and PI-3K through its cytoplasmic tyrosine kinase-containing region. HER2 is expressed by bone marrow mesenchymal stem cells. It is overexpressed and plays a significant role in the development of multiple human cancers including some leukemias, neuroblastomas, and carcinomas.
The Trastuzumab.rMAb is intended for research use only. It is not intended for use in therapeutic or diagnostic procedures for humans or animals.
研发参考 (3)
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Carter P, Presta L, Gorman CM, et al. Humanization of an anti-p185HER2 antibody for human cancer therapy.. Proc Natl Acad Sci U S A. 1992; 89(10):4285-9. (Biology). 查看参考
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Goldenberg MM. Trastuzumab, a recombinant DNA-derived humanized monoclonal antibody, a novel agent for the treatment of metastatic breast cancer.. Clin Ther. 1999; 21(2):309-18. (Biology). 查看参考
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Stancovski I, Hurwitz E, Leitner O, Ullrich A, Yarden Y, Sela M. Mechanistic aspects of the opposing effects of monoclonal antibodies to the ERBB2 receptor on tumor growth.. Proc Natl Acad Sci USA. 1991; 88(19):8691-5. (Biology). 查看参考
Please refer to Support Documents for Quality Certificates
Global - Refer to manufacturer's instructions for use and related User Manuals and Technical data sheets before using this products as described
Comparisons, where applicable, are made against older BD Technology, manual methods or are general performance claims. Comparisons are not made against non-BD technologies, unless otherwise noted.
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
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