BD FACSLyric™ Clinical Flow Cytometry System

Discover how this flow cytometer can transform your clinical lab with outstanding performance, automation and standardization

Discover the BD FACSLyric™ Flow Cytometry System difference

Witness clinical performance results you have never seen before through high sensitivity and improved resolution
Streamline your lab workflow through flexibility and automation, enabling efficiency and productivity
Achieve automated standardization through highly reproducible results and enable collaboration through assay portability
See how the BD FACSLyric™ System can transform your lab

Get more information from the BD FACSLyric™ Flow Cytometry System Brochure

Features

Discover the BD FACSLyric™ Flow Cytometry System—A Next-Generation Flow Cytometer

Built on a foundation of excellence, experience and expertise, the BD FACSLyric™ Flow Cytometry System is a new standard for cell analysis, transforming the way your lab does flow cytometry. As with all BD instruments, the BD FACSLyric™ Flow Cytometry System is backed by 40 years of BD expert training, service and support—so there’s no limit to your potential.

The Power of the BD FACSLyric™ Flow Cytometer

4-, 6-, 8-, 10- and 12-color configurations. Onsite upgradeable to adapt to your lab's changing needs
Up to 3 lasers—blue, red and violet—12 fluorescence channels and 14 parameters
35,000 events per second maximum acquisition rate; no limit on number of events acquired
Automated single-tube QC with BD^® CS&T Beads
Fluorescence compensation required only every 60 days, improving efficiency and productivity
21 different loading options: plates or tubes; built-in flexibility with BD FACS™ Universal Loader
Powered by the BD FACSuite™ Acquisition and Analysis Application, whose password protection, audit trail, electronic signatures and IQ/OQ procedures assist in supporting U.S, FDA 21 CFR Part 11 compliance
BD FACSLink™ Laboratory Information System (LIS) Interface and BD Assurity Linc™ Remote Systems Management Software streamline your workflow and help improve productivity through seamless integration

See how you can simplify your workflow using the automated instrument setup and compensation on the BD FACSLyric™ System

Performance

A new diagnostic standard delivering outstanding performance and standardization within and between instruments

The BD FACSLyric™ Flow Cytometry System is a high-performance, highly sensitive flow cytometer that demonstrates exceptional resolution and improved separation to make dim and rare cell populations easier to resolve.

BD FACSLyric™ and BD FACSCanto™ datatables.

Higher sensitivity makes dim and rare populations easier to resolve.

Graph of BD FACSLyric™ and BD FACSCanto™ II performance.

Improvement in stain index of 8–190% across all parameters ensures better separation and enables faster analysis and easier gating.

CD23 PE, Lambda PE, CD5 BV421 datatables.

Assay portability simplifies and standardizes instrument setup within your lab and between labs. It also enables the sharing and exchange of data, ideas, and IVD and user-defined protocols within and between institutions.

Highly reproducible results between instruments drive standardization

BD FACSLyric™ System Variance (CVs)

15 BD FACSLyric™ Systems: Lyse/Wash settings and BD FC^® Beads

Blue Laser	%CV
FITC	4.2
PE	4.4
PE-Cy7	4.8
PerCP	10.2
PerCP-Cy5.5	7.9

Red Laser	%CV
APC	5.3
APC-Cy7	4.1
APC-H7	3.9
APC-R700	4.2

Violet Laser	%CV
BD Horizon™ V450	11.1
BD Horizon™ V500	11
BD Horizon™ BV605	13.6
BD Horizon™ BV711	7.5
BD Horizon™ BV786	15.3

Between-instrument reproducibility of target MFI values on the BD FACSLyric™ System

Lyse/wash assay settings were imported across 15 instruments to show effects of standardization on beads. The CVs of the fluorescence intensity across all channels varies by less than 15.3%. Daily QC with one lot of BD^® Cytometer Setup & Tracking Beads was run on fifteen BD FACSLyric™ Flow Cytometers. For each instrument, the PMTV gains were automatically adjusted to meet the target values. BD^® FC Beads acquired on each BD FACSLyric™ Instrument. The MFI of positive populations was measured for all parameters across all instruments. The %CV is shown. The data for this internal study were acquired using BD^® FC Beads across 15 BD FACSLyric™ Instruments. Greater between-instrument variability could be observed when running biological samples, when using non BD reagents or when comparing fewer instruments.

Applications

A Powerful Solution for CD4 Counts and Other Immunological Assessment

With the BD FACSLyric™ Flow Cytometer, clinical laboratories can obtain repeatable and reliable results for immunological assessment of patients having or suspected of having an immune deficiency such as HIV.

The BD FACSLyric™ Flow Cytometry System delivers improved clinical performance and accuracy in diagnosis with increased process efficiency and standardization.

BD Multitest™ Reagents, formulated to be used with BD Trucount™ Tubes, provide absolute counting capability.
The BD FACSuite™ Clinical Application, with predefined templates for 4- and 6-color T, B and/or NK cell analysis, provides reproducible and consistent results.
Each reagent includes a cocktail of multiple fluorescently labeled monoclonal antibodies, premixed at the appropriate titer to ensure quality staining.

A streamlined methodology for immunological assessment of patients having or suspected of having an immune deficiency such as HIV using the BD FACSLyric™ Flow Cytometer.

"BD is positioned with BD^® CS&T and BD^® FC Bead technology to enable instrument standardization simply from day to day, instrument to instrument, and lab to lab."

Dr. Lili Wang

NIST

Gaithersburg, MD

“The consistency and the regulatory compliance of FACSLyric [Flow Cytometer]’s output is what really drew us to the platform. It is currently unmatched by other flow cytometers in its ability to generate reliable, repeatable results across tests and instruments—even for the most complex assays we deal with day to day. We’ve found it particularly beneficial for multiparameter testing for CAR T cells and immunophenotyping.”

Dr. Arno Kromminga

Chief Scientific Officer, BioAgilytix

Europe

“The assay portability of BD FACSLyric is the key to efficient method transfer and high data reproducibility. It represents a clear advantage in a regulated environment, where conditions must be met to produce valid results of a guaranteed level of quality. Functional immune cell–based assays and cytokine quantification in preclinical and clinical drug development is a particularly important area where BD FACSLyric offers clear technical advantages.”