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      Purified Rat Anti-Human IL-12Rβ2
      商品详情
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      BD Pharmingen™
      IL12RB2; Interleukin-12 receptor beta-2 chain
      Human (QC Testing)
      Rat IgG2a, κ
      Human IL-12Rβ2 Recombinant Protein
      Flow cytometry (Routinely Tested), Fluorescence microscopy (Reported)
      0.5 mg/ml
      AB_393850
      Aqueous buffered solution containing ≤0.09% sodium azide.
      RUO


      商品通知

      1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
      2. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
      3. Please refer to www.bdbiosciences.com/us/s/resources for technical protocols.
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      550722 Rev. 6
      抗体详情
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      2B6/12beta2

      The 2B6 monoclonal antibody specifically recognizes the Interleukin 12 Receptor beta 2 subunit (IL-12Rβ2). IL-12Rβ2 serves as the signaling subunit that combines with CD212 (Interleukin 12 Receptor beta 1 subunit/ IL-12Rβ1) to form the functional receptor for IL-12. The IL-12Rβ2 is expressed on T cells and NK cells. IL-12R is a glycoprotein member of the hemopoietin receptor superfamily and is related to gp130, the granulocyte-colony stimulating factor (G-CSF) receptor and leukemia inhibitory factor (LIF). IL-12 is an immunomodulatory cytokine produced mainly by antigen presenting cells (APC) and plays a role in promoting Th1-type responses and cell mediated immunity. It stimulates proliferation of T cells and NK cells, enhances lytic activity of lymphokine activated (LAK) cells and cytolytic T cells (CTL).

      550722 Rev. 6
      格式详情
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      Purified
      Tissue culture supernatant is purified by either protein A/G or affinity purification methods. Both methods yield antibody in solution that is free of most other soluble proteins, lipids, etc. This format provides pure antibody that is suitable for a number of downstream applications including: secondary labeling for flow cytometry or microscopy, ELISA, Western blot, etc.
      Purified
      550722 Rev.6
      报价单和参考
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      研发参考 (4)

      1. Chizzonite R, Truitt T, Podlaski FJ, et al. IL-12: monoclonal antibodies specific for the 40-kDa subunit block receptor binding and biologic activity on activated human lymphoblasts. J Immunol. 1991; 147(5):1548-1556. (Biology). 查看参考
      2. Chua AO, Chizzonite R, Desai BB, et al. Expression cloning of a human IL-12 receptor component. A new member of the cytokine receptor superfamily with strong homology to gp130. J Immunol. 1994; 153(1):128-136. (Biology). 查看参考
      3. Presky DH, Minetti LJ, Gillessen S, et al. Analysis of the multiple interactions between IL-12 and the high affinity IL-12 receptor complex. J Immunol. 1998; 160(5):2174-2179. (Biology). 查看参考
      4. Wu CY, Warrier RR, Carvajal DM, et al. Biological function and distribution of human interleukin-12 receptor beta chain. Eur J Immunol. 1996; 26(2):345-350. (Biology). 查看参考
      查看所有文件 (4) 查看更少内容
      550722 Rev. 6

      Please refer to Support Documents for Quality Certificates


      Global - Refer to manufacturer's instructions for use and related User Manuals and Technical data sheets before using this products as described


      Comparisons, where applicable, are made against older BD Technology, manual methods or are general performance claims.  Comparisons are not made against non-BD technologies, unless otherwise noted.

      For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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