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Western blot analysis of BAF60a on jurkat lysate. Lane 1: 1:500, lane 2: 1:1000, lane 3: 1:2000 dilution of BAF60a.
Human Endothelial
BD Transduction Laboratories™ Purified Mouse Anti- BAF60a
BD Transduction Laboratories™ Purified Mouse Anti- BAF60a
监管状态图例
未经BD明确书面授权,严禁使用未经许可的任何商品。
准备和存储
商品通知
- Since applications vary, each investigator should titrate the reagent to obtain optimal results.
- Please refer to www.bdbiosciences.com/us/s/resources for technical protocols.
- Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
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SWI/SNF complexes facilitate gene activation and transcription factor binding byaltering repressive chromatin structures. In mammals, SWI/SNF complexes are present inmutliple forms that include 9-12 proteins called BRG1-associated factors (BAFs), whichrange in molecular weight from 47 to 250 kDa. BAF60 is the homologue of the yeastSWP70 subunit of the yeast SWI/SNF complex that regulates glucocorticoidtranscription. Three isoforms of BAF60 are BAF60a, BAF60b, and BAF60c. BAF60a isubiquitously expressed and is present in the 200-kDa BRG1 complex. BAF60b andBAF60c are expressed preferentially in muscle and pancreas and may be subunits of adistinct complex that shares some subunits with BRG1 complex. In hematopoietic cells,a SWI/SNF related-complex (PYR) contains BAF57, INI1, BAF60a, and BAF170. This complex binds a 250 bp pyrimidine-rich element between the fetal and adult ß-globingenes and may facilitate human fetal-to-adult globin gene switching. Thus, BAF60proteins are components of multiple SWI/SNF complexes that regulate the transcriptionof various genes.
研发参考 (3)
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O'Neill D, Yang J, Erdjument-Bromage H, Bornschlegel K, Tempst P, Bank A. Tissue-specific and developmental stage-specific DNA binding by a mammalian SWI/SNF complex associated with human fetal-to-adult globin gene switching. Proc Natl Acad Sci U S A. 1999; 96(2):349-354. (Biology). 查看参考
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Wang W, Cote J, Xue Y, et al. Purification and biochemical heterogeneity of the mammalian SWI-SNF complex. EMBO J. 1996; 15(19):5370-5382. (Biology). 查看参考
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Wang W, Xue Y, Zhou S, Kuo A, Cairns BR, Crabtree GR. Diversity and specialization of mammalian SWI/SNF complexes. Genes Dev. 1996; 10(17):2117-2130. (Biology). 查看参考
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