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![Purified Mouse Anti-Human CD95](/content/dam/bdb/products/global/reagents/flow-cytometry-reagents/research-reagents/single-color-antibodies-ruo/550xxx/5500xx/550042_base/37671A_550042_image1.png)
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Jurkat cells treated for 6 hours with CD95 (EOS9.1)
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Jurkat cells treated for 6 hours with mouse IgM isotype control
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BD Pharmingen™ Purified Mouse Anti-Human CD95
![Purified Mouse Anti-Human CD95](/content/dam/bdb/products/global/reagents/flow-cytometry-reagents/research-reagents/single-color-antibodies-ruo/550xxx/5500xx/550042_base/37671A_550042_image2.png)
BD Pharmingen™ Purified Mouse Anti-Human CD95
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监管状态图例
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准备和存储
商品通知
- Since applications vary, each investigator should titrate the reagent to obtain optimal results.
- Please refer to www.bdbiosciences.com/us/s/resources for technical protocols.
配套商品
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Reacts with a 45 kD type I membrane molecule also known as APO-1, or Fas antigen. CD95 belongs to the tumor necrosis factor receptor (TNF-R) family of proteins and is expressed on various cells, including activated T cells and B cells. The interaction of CD95, Fas antigen, with Fas ligand is one of the many mechanisms that lead to apoptosis or programmed cell death. The interaction of CD95 expressing target cells with Fas ligand on cytotoxic T cells induces an apoptotic signal leading to target cell death. It has been reported that apoptosis is the mechanism used by the immune system in clonal deletion of self-reactive T cells during embryological development.
研发参考 (4)
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Kishimoto T. Tadamitsu Kishimoto .. et al., ed. Leucocyte typing VI : white cell differentiation antigens : proceedings of the sixth international workshop and conference held in Kobe, Japan, 10-14 November 1996. New York: Garland Pub.; 1997.
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Krammer PH, Dhein J, Walczak H. The role of APO-1-mediated apoptosis in the immune system. Immunol Rev. 1994; (142):175-191. (Biology). 查看参考
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Nagata S, Golstein P. The Fas death factor. Science. 1995; 267(5203):1449-1456. (Biology). 查看参考
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Rouvier E, Luciani MF, Golstein P. Fas involvement in Ca(2+)-independent T cell-mediated cytotoxicity. J Exp Med. 1993; 177(1):195-200. (Biology). 查看参考
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