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BD Pharmingen™ Purified Mouse Anti-Human CD328
克隆 F023-420 (RUO)




Profile of human Siglec-7 (clone F023-420) reactivity on peripheral blood lymphocytes analyzed by flow cytometry. Second step staining with Cat. No. 555988.


BD Pharmingen™ Purified Mouse Anti-Human CD328

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准备和存储
商品通知
- Since applications vary, each investigator should titrate the reagent to obtain optimal results.
- Please refer to www.bdbiosciences.com/us/s/resources for technical protocols.
- Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
配套商品



The F023-420 monoclonal antibody specifically recognizes CD328 which is also known as sialic acid binding Ig like lectin 7 (Siglec-7). CD238 is an I-type lectin of approximately 65 kDa, expressed as a monomer on a major subset of NK cells and a subset of CD8+ cells. It is also expressed at moderate levels on monocytes and weakly on granulocytes. Siglecs (sialic acid/immunoglobulin/lectin) are a family of I-type lectins that bind to sialic acids on the cell surface. They are a family of carbohydrate binding proteins within the immunoglobulin superfamily. Siglecs are integral membrane proteins with extracellular N-terminal, V-set Ig domains, followed by variable numbers of C2-set Ig domains.
研发参考 (4)
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Angata T, Hingorani R, Varki NM, Varki A. Cloning and characterization of a novel mouse Siglec, mSiglec-F: differential evolution of the mouse and human (CD33) Siglec-3-related gene clusters. J Biol Chem. 2001; 276(48):45128-45136. (Biology). 查看参考
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Crocker PR, Varki A. Siglecs, sialic acids and innate immunity. Trends Immunol. 2001; 22(6):337-342. (Biology). 查看参考
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Nicoll G, Ni J, Liu D, et al. Identification and characterization of a novel siglec, siglec-7, expressed by human natural killer cells and monocytes. J Biol Chem. 1999; 274(48):34089-34095. (Biology). 查看参考
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Powell LD, Varki A. I-type lectins. J Biol Chem. 1995; 270(24):14243-14246. (Biology). 查看参考
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For Research Use Only. Not for use in diagnostic or therapeutic procedures.