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PerCP Mouse Anti-Human CD42a
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GPIX; GP9; Glycoprotein IX
Mouse BALB/c IgG1, κ
Normal Human Platelets
Flow cytometry
12.5 μg/mL
20 μL
Phosphate buffered saline with gelatin and 0.1% sodium azide.


Store vials at 2°C–8°C. Conjugated forms should not be frozen. Protect from exposure to light. Each reagent is stable until the expiration date shown on the bottle label when stored as directed.

340537 Rev. 1
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The CD42a antibody, clone Beb1, is derived from hybridization of Sp2/0 mouse myeloma cells with spleen cells from BALB/c mice immunized with normal human platelets.

The CD42a antibody recognizes a 17 to 22-kilodalton (kDa) single-chain, platelet membrane glycoprotein, also known as gpIX that forms a noncovalent complex with gpIb and gpV. Glycoprotein Ib consists of an α–chain disulfide-linked to a β chain. Glycoproteins Ibα (140 to 145 kDa), Ibβ (24 to 25 kDa), and V (82 to 86 kDa) have been designated as CD42b, CD42c and CD42d respectively. CD42a has been reported to react with both gpIX and the gpIb-IX-V complex.

340537 Rev. 1
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PerCP dye is part of the BD blue family of dyes. This dye is a fluorescent protein complex with an excitation maximum (Ex Max) of 481 nm and an emission maximum (Em Max) at 675 nm. PerCP is designed to be excited by the blue laser (488 nm) and detected using an optical filter centered near 680 nm (e.g., a 695/40 nm bandpass filter). The donor dye can be partially excited by the Violet (405 nm) laser resulting in cross-laser excitation and fluorescence spillover. Please ensure that your instrument’s configurations (lasers and optical filters) are appropriate for this dye.
Blue 488 nm
481 nm
675 nm
340537 Rev.1
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研发参考 (15)

  1. Nieuwenhuis HK. Report on functional studies. In: Knapp W. W. Knapp .. et al., ed. Leucocyte typing IV : white cell differentiation antigens. Oxford New York: Oxford University Press; 1989:1002-1003.
  2. Centers for Disease Control. Update: universal precautions for prevention of transmission of human immunodeficiency virus, hepatitis B virus, and other bloodborne pathogens in healthcare settings. MMWR. 1988; 37:377-388. (Biology).
  3. Clinical and Laboratory Standards Institute. 2005. (Biology).
  4. Du X, Beutler L, Ruan C, Castaldi PA, Berndt MC. Glycoprotein Ib and glycoprotein IX are fully complexed in the intact platelet membrane.. Blood. 1987; 69(5):1524-7. (Biology). 查看参考
  5. Fox JE, Aggerbeck LP, Berndt MC. Structure of the glycoprotein Ib.IX complex from platelet membranes. J Biol Chem. 1988; 263(10):4882-4890. (Biology). 查看参考
  6. Hickey MJ, Williams SA, Roth GJ. Human platelet glycoprotein IX: an adhesive prototype of leucine-rich glycoproteins with flank-center-flank structures. Proc Natl Acad Sci U S A. 1989; 86(17):6773-6777. (Biology). 查看参考
  7. Hourdillé P, Heilmann E, Combrié R, Winckler J, Clemetson KJ, Nurden AT. Thrombin induces a rapid redistribution of glycoprotein Ib-IX complexes within the membrane systems of activated human platelets.. Blood. 1990; 76(8):1503-13. (Biology). 查看参考
  8. Michelson AD, Benoit SE, Furman MI, Barnard MR, Nurden P, Nurden AT. The platelet surface expression of glycoprotein V is regulated by two independent mechanisms: proteolysis and a reversible cytoskeletal-mediated redistribution to the surface-connected canalicular system.. Blood. 1996; 87(4):1396-408. (Biology). 查看参考
  9. Michelson AD, Benoit SE, Kroll MH, et al. The activation-induced decrease in the platelet surface expression of the glycoprotein Ib-IX complex is reversible.. Blood. 1994; 83(12):3562-73. (Biology). 查看参考
  10. Michelson AD, Ellis PA, Barnard MR, Matic GB, Viles AF, Kestin AS. Downregulation of the platelet surface glycoprotein Ib-IX complex in whole blood stimulated by thrombin, adenosine diphosphate, or an in vivo wound.. Blood. 1991; 77(4):770-9. (Biology). 查看参考
  11. Modderman PW, Admiraal LG, Sonnenberg A, von dem Borne AE. Glycoproteins V and Ib-IX form a noncovalent complex in the platelet membrane.. J Biol Chem. 1992; 267(1):364-9. (Biology). 查看参考
  12. Ruggeri ZM. The platelet glycoprotein Ib-IX complex.. Prog Hemost Thromb. 1991; 10:35-68. (Biology). 查看参考
  13. Silverstein RL. Schlossman S, Boumsell L, Gilks W, ed. Leucocyte Typing V: White Cell Differentiation Antigens. New York, NY: Oxford University Press; :995:1197.
  14. Yamamoto N, Greco NJ, Barnard MR, et al. Glycoprotein Ib (GPIb)-dependent and GPIb-independent pathways of thrombin-induced platelet activation.. Blood. 1991; 77(8):1740-8. (Biology). 查看参考
  15. von dem Borne AEGKr, Modderman PW. Knapp W, Dörken B, Gilks WR, et al, ed. Leucocyte Typing IV: White Cell Differentiation Antigens. New York, NY: Oxford University Press; 1989:1000-1002.
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340537 Rev. 1

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