Skip to main content Skip to navigation
FITC Mouse Anti-Human PAC-1
商品详情
Down Arrow Up Arrow


BD™
Human
Mouse BALB/c IgM, κ
Human platelets
Flow cytometry
25 µg/mL
20 μL
3674,3690
AB_2230769
Phosphate buffered saline with gelatin and 0.1% sodium azide.
RUO (GMP)


准备和存储

Store vials at 2°C–8°C. Conjugated forms should not be frozen. Protect from exposure to light. Each reagent is stable until the expiration date shown on the bottle label when stored as directed. Please refer to the vial label for antibody concentration.

340507 Rev. 1
抗体详情
Down Arrow Up Arrow
PAC-1

The PAC-1 antibody is derived from the fusion of SP-2 mouse myeloma cells with splenic lymphocytes from BALB/c mice that were immunized with human platelets.

The PAC-1 recognizes an epitope on the glycoprotein IIb/IIIa (gpIIb/IIIa, αIIbβ3) complex of activated platelets at or near the platelet fibrinogen receptor.

340507 Rev. 1
格式详情
Down Arrow Up Arrow
FITC
Fluorescein (FITC) is part of the BD blue family of dyes. This is a small organic fluorochrome with an excitation maximum (Ex Max) at 494-nm and an emission maximum (Em Max) at 518-nm. FITC is designed to be excited by the Blue laser (488-nm) and detected using an optical filter centered near 520 nm (e.g., a 530/30-nm bandpass filter). Please ensure that your instrument’s configurations (lasers and optical filters) are appropriate for this dye.
altImg
FITC
Blue 488 nm
494 nm
518 nm
340507 Rev.1
报价单和参考
Down Arrow Up Arrow
View product citations for antibody "340507" on CiteAb

研发参考 (18)

  1. Abrams C, Deng Y-J, Steiner B, O’Toole T, Shattil SJ. Determinants of specificity of a baculovirus-expressed antibody Fab fragment that binds selectively to the activated form of integrin αIIb β3. J Biol Chem. 1994; 269:18781-18788. (Biology).
  2. Abrams C, Shattil SJ. Immunological detection of activated platelets in clinical disorders. Thrombosis and Haemostasis. 1991; 65:467-473. (Biology).
  3. Abrams CS, Ellison N, Budzynski AZ, Shattil SJ. Direct detection of activated platelets and platelet-derived microparticles in humans.. Blood. 1990; 75(1):128-38. (Biology). 查看参考
  4. Abrams CS, Ruggeri ZM, Taub R, et al. Anti-idiotypic antibodies against an antibody to the platelet glycoprotein (GP) IIb-IIIa complex mimic GP IIb-IIIa by recognizing fibrinogen. J Biol Chem. 1990; 75:128-138. (Biology).
  5. Bennett JS, Shattil SJ, Power JW, Gartner TK. Interaction of fibrinogen with its platelet receptor. J Biol Chem. 1988; 263:12948-12953. (Biology).
  6. Centers for Disease Control. Perspectives in disease prevention and health promotion update: universal precautions for prevention of transmission of human immunodeficiency virus, hepatitis B virus, and other bloodborne pathogens in health-care settings. MMWR. 1988; 37:377-388. (Biology).
  7. Clinical and Laboratory Standards Institute. 2005. (Biology).
  8. Ginsberg MH, Frelinger AL, Lam S, et al. Analysis of platelet aggregation disorders based on flow cytometric analysis of membrane glycoprotein IIb-IIIa with conformation-specific monoclonal antibodies. Blood. 1990; 76:2017-2023. (Biology).
  9. Huang M-M, Lipfert L, Cunningham M, et al. Adhesive ligand binding to integrin αIIbβ3 stimulates tyrosine phosphorylation of novel protein substrates before phosphorylation of pp125FAK. J Cell Biol. 1993; 122:473-483. (Biology).
  10. Hynes RO. Integrins: versatility, modulation, and signaling in cell adhesion. Cell. 1992; 69(1):11-25. (Biology). 查看参考
  11. Michelson AD. Flow cytometry: A clinical test of platelet function. Blood. 1996; 87:4925-4936. (Biology).
  12. O’Toole TE, Mandelman D, Forsyth J, et al. Modulation of the affinity of integrin α IIb β 3 (GPIIb-IIIa) by the cytoplasmic domain of αIIb. Science. 1991; 254:845-847. (Biology).
  13. Shattil SJ, Cunningham M, Hoxie JA. Detection of activated platelets in whole blood using activation-dependent monoclonal antibodies and flow cytometry. Blood. 1987; 70:307-315. (Biology).
  14. Shattil SJ, Cunningham M. Wiedmer T, et al. Regulation of glycoprotein IIb-IIIa receptor function studied with platelets permeabilized by the pore-forming complement proteins C5b-9. J Biol Chem. 1992; 267:18424-18431. (Biology).
  15. Shattil SJ, Hoxie JA, Cunningham M, Brass LF. Changes in the platelet membrane glycoprotein IIb.IIIa complex during platelet activation.. J Biol Chem. 1985; 260(20):11107-14. (Biology). 查看参考
  16. Shattil SJ, Weisel JW, Kieber-Emmons T. Use of monoclonal antibodies to study the interaction between an integrin adhesion receptor, GP IIb-IIIa, and its physiological ligand, fibrinogen. Immunomethods. 1993; 1:53-63. (Biology).
  17. Springer TA. Adhesion receptors of the immune system. Nature. 1990; 346(6283):425-434. (Biology). 查看参考
  18. Taub R, Gould RJ, Garsky VM, et al. A monoclonal antibody against the platelet fibrinogen receptor contains a sequence that mimics a receptor recognition domain in fibrinogen. J Biol Chem. 1989; 264:259-265. (Biology).
查看所有文件 (18) 查看更少内容
340507 Rev. 1

Please refer to Support Documents for Quality Certificates


Global - Refer to manufacturer's instructions for use and related User Manuals and Technical data sheets before using this products as described


Comparisons, where applicable, are made against older BD Technology, manual methods or are general performance claims.  Comparisons are not made against non-BD technologies, unless otherwise noted.

For Research Use Only. Not for use in diagnostic or therapeutic procedures. 

 

Although not required, these products are manufactured in accordance with Good Manufacturing Practices.