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CD200 PE-Cy™7
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OX-2; MOX1; MOX2 ; My033
Mouse IgG1, κ
Human CD200 Recombinant Protein
Flow cytometry
100 μg/mL
5 μL
VII 70655; IX 40

655735 Rev. 1
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MRC OX-104

The CD200 antibody, clone MRC OX-104, is derived from hybridization of mouse NS-1 myeloma cells with spleen cells isolated from a mouse immunized with a recombinant fusion protein containing the two IgSF domains comprising the human CD200 extracellular region.

The CD200 antibody specifically binds to a 40–45 kilodalton (kDa) type 1 transmembrane glycoprotein containing two immunoglobulin superfamily domains (IgSF), and a short cytoplasmic tail. The CD200 antigen is also known as OX-2, MOX1, and MOX2.

655735 Rev. 1
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PE-Cy7 dye is a part of the BD PE family of dyes. This tandem fluorochrome is comprised of a R-Phycoerythrin (PE) donor that has excitation maxima (Ex Max) of 496-nm and 566-nm and an acceptor dye, Cy™7, with an emission maximum (Em Max) at 781-nm. PE can be excited by the Blue (488-nm), Green (532-nm) and yellow-green (561-nm) lasers and detected using an optical filter centered near 781 nm (e.g., a 760/60-nm bandpass filter). The donor dye can be excited by the Blue (488-nm), Green (532-nm) and yellow-green (561-nm) lasers and the acceptor dye can be excited by the Red (627–640-nm) laser resulting in cross-laser excitation and fluorescence spillover. Please ensure that your instrument’s configurations (lasers and optical filters) are appropriate for this dye.
Yellow-Green 488 nm, 532 nm, 561 nm
496 nm, 566 nm
781 nm
655735 Rev.1
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研发参考 (8)

  1. Barclay AN, Wright GJ, Brown MH. CD200 (OX2) Summary and Workshop report: The lymphoid/ neuronal OX2 glycoprotein (CD200) interacts with a novel receptor on macrophages. In: Mason D. David Mason .. et al., ed. Leucocyte typing VII : white cell differentiation antigens : proceedings of the Seventh International Workshop and Conference held in Harrogate, United Kingdom. Oxford: Oxford University Press; 2002:471-473.
  2. Borriello F, Lederer J, Scott S, Sharpe AH. MRC OX-2 defines a novel T cell co-stimulatory pathway. J Immunol. 1997; 158:4548-4554. (Biology).
  3. Centers for Disease Control. Update: universal precautions for prevention of transmission of human immunodeficiency virus, hepatitis B virus, and other bloodborne pathogens in healthcare settings. MMWR. 1988; 37:377-388. (Biology).
  4. Clark MJ, Gagnon J, Williams AF, Barclay AN. MRC OX-2 antigen: a lymphoid/neuronal membrane glycoprotein with a structure like a single immunoglobulin light chain. EMBO J. 1985; 4:113-118. (Biology).
  5. Clinical and Laboratory Standards Institute. 2005. (Biology).
  6. Hoek RM, Ruuls SR, Murphy CA, et al. Down-regulation of the macrophage lineage through interaction with OX2 (CD200).. Science. 2000; 290(5497):1768-71. (Biology). 查看参考
  7. Wright GJ, Jones M, Puklavec MJ, Brown MH, Barclay AN. The unusual distribution of the neuronal/lymphoid cell surface CD200 (OX2) glycoprotein is conserved in humans. Immunology. 2001; 102(2):173-179. (Biology). 查看参考
  8. Wright GJ, Puklavec MJ, Willis AC, et al. Lymphoid/neuronal cell surface OX2 glycoprotein recognizes a novel receptor on macrophages implicated in the control of their function. Immunity. 2000; 13(2):233-242. (Biology). 查看参考
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655735 Rev. 1

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