Anti-HER-2/neu PE

BD™ Anti-HER-2/neu PE

Name: Anti-HER-2/neu PE
Brand: BD™
SKU: 340879

克隆 NEU 24.7

(ASR)

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科学资源

商品详情

Brand: BD™

Alternative Name: HER2; NEU; ERBB2; p185HER2; erb-b2 receptor tyrosine kinase 2; CD340

Reactivity: Human

Isotype: Mouse BALB/c IgG1

Immunogen: SKBR3 human breast carcinoma cells

Application: Flow cytometry

Concentration: 5 μg/mL

Vol. Per Test: 20 μL

Entrez Gene ID: 2064

Storage Buffer: Phosphate buffered saline with gelatin and 0.1% sodium azide.

Regulatory Status: ASR

准备和存储

Vials should be stored at 2° to 8°C. Conjugated forms should not be frozen and should be protected from prolonged exposure to light. Each reagent is stable for the period shown on the bottle label when stored as directed.

340879 Rev. 1

抗体详情

NEU 24.7

Anti–HER-2/neu, clone Neu 24.7, is derived from the fusion of NSO myeloma cells with spleen cells from BALB/c mice injected with living SKBR3 human breast carcinoma cells.

Anti–HER-2/neu recognizes a single protein of 185 kdaltons from HER-2 transfected cells.

340879 Rev. 1

格式详情

R-Phycoerythrin (PE), is part of the BD family of Phycobiliprotein dyes. This fluorochrome is a multimeric fluorescent phycobiliprotein with excitation maximum (Ex Max) of 496 nm and 566 nm and an emission maximum (Em Max) at 576 nm. PE is designed to be excited by the Blue (488 nm), Green (532 nm) and Yellow-Green (561 nm) lasers and detected using an optical filter centered near 575 nm (e.g., a 575/26-nm bandpass filter). As PE is excited by multiple lasers, this can result in cross-laser excitation and fluorescence spillover on instruments with various combinations of Blue, Green, and Yellow-Green lasers. Please ensure that your instrument’s configurations (lasers and optical filters) are appropriate for this dye.

格式: PE

激发源: Yellow-Green 488 nm, 532 nm, 561 nm

最多激发源: 496 nm, 566 nm

最多发射源: 576 nm

340879 Rev.1

报价单和参考

研发参考 (3)

Fendly BM, Kotts C, Vetterlein D, et al. The extracellular domain of HER2/neu is a potential immunogen for active specific immunotherapy of breast cancer. J Biol Response Mod. 1990; 9(5):449-455. (Biology). 查看参考
Stancovski I, Hurwitz E, Leitner O, Ullrich A, Yarden Y, Sela M. Mechanistic aspects of the opposing effects of monoclonal antibodies to the ERBB2 receptor on tumor growth.. Proc Natl Acad Sci USA. 1991; 88(19):8691-5. (Biology). 查看参考
Szollosi J, Balazs M, Feuerstein BG, Benz CC, Waldman FM. ERBB-2 (HER2/neu) gene copy number, p185HER-2 overexpression, and intratumor heterogeneity in human breast cancer. Cancer Res. 1995; 55(22):5400-5407. (Biology). 查看参考

340879 Rev. 1

Please refer to Support Documents for Quality Certificates

Global - Refer to manufacturer's instructions for use and related User Manuals and Technical data sheets before using this products as described

Comparisons, where applicable, are made against older BD Technology, manual methods or are general performance claims. Comparisons are not made against non-BD technologies, unless otherwise noted.