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BD Transduction Laboratories™ Purified Mouse Anti-Neuronal Pentraxin
Clone 22/Neuronal Pentraxin
(RUO)Western blot analysis of Neuronal Pentraxin on rat brain lysate. Lane 1: 1:1000, lane 2: 1:2000, lane 3: 1:4000 dilution of Neuronal Pentraxin.
Rat Brain
BD Transduction Laboratories™ Purified Mouse Anti-Neuronal Pentraxin
BD Transduction Laboratories™ Purified Mouse Anti-Neuronal Pentraxin
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제품 고시
- Since applications vary, each investigator should titrate the reagent to obtain optimal results.
- Please refer to www.bdbiosciences.com/us/s/resources for technical protocols.
- Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
- Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Neuronal pentraxin (NP) is a potential receptor for the snake venom toxin, taipoxin. The highest levels of NP mRNA are found in the cerebellum and the CA3 region of the hippocampus. More specifically, NP mRNA is expressed at high levels in Purkinje and granule neurons of the cerebellum and CA3 neurons of the hippocampus. Moderate levels are present in neurons of the hilus, dentate gyrus, CA1, cerebral cortex, medial habenula, anterior hypothalamic nuclei, olfactory cortex, and inferior olivary nuclei. NP mRNA is not expressed in glia of white or gray matter. It is thought that NP serves as a receptor for taipoxin and, after binding, NP-taipoxin is taken into presynaptic terminals. Alternatively, the binding of taipoxin by NP may represent a nonspecific mechanism to sequester toxins from synapses.
개발 참고 자료 (2)
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DeGregorio-Rocasolano N, Gasull T, Trullas R. Overexpression of neuronal pentraxin 1 is involved in neuronal death evoked by low K(+) in cerebellar granule cells. Neuron. 2001; 276(1):796-803. (Clone-specific: Western blot). 참조 보기
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Schlimgen AK, Helms JA, Vogel H, Perin MS. Neuronal pentraxin, a secreted protein with homology to acute phase proteins of the immune system. Neuron. 1995; 14(3):519-526. (Biology). 참조 보기
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