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Western blot analysis of Ezrin on MDCK lysate. Lane 1: 1:250, lane 2: 1:500, lane 3: 1:1000 dilution of anti-Ezrin.
Immunofluorescent staining of HeLa cells with anti-Ezrin antibody.
BD Transduction Laboratories™ Purified Mouse Anti-Ezrin
BD Transduction Laboratories™ Purified Mouse Anti-Ezrin
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First described as an 80kDa protein concentrated in the apical cytoskeletal region of intestinal brush border cells, ezrin is now recognized as a major substrate of protein tyrosine kinases, such as the epidermal growth factor (EGF) tyrosine kinase. Ezrin is expressed at high levels in intestine, kidney, and placenta. In placenta, ezrin is present as monomers and non-covalent oligomers in tight association with actin microfilaments. In the human epidermoid carcinoma cell line A431, microvilli-like structures appear within 30 seconds after the addition of EGF. These structures give way to membrane ruffles after 2-5 minutes, followed by cell rounding after 10-20 minutes. At the same time, ezrin is recruited into these structures and oligomers are formed following its tyrosine phosphorylation. It is thought that tyrosine phosphorylation triggers the formation of ezrin oligomers.
개발 참고 자료 (5)
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Anastasiadis PZ, Moon SY, Thoreson MA, et al. Inhibition of RhoA by p120 catenin. Nat Cell Biol. 2000; 2(9):637-644. (Clone-specific: Immunofluorescence). 참조 보기
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Berryman M, Gary R, Bretscher A. Ezrin oligomers are major cytoskeletal components of placental microvilli: a proposal for their involvement in cortical morphogenesis. J Cell Biol. 1995; 131(5):1231-1242. (Biology). 참조 보기
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Defacque H, Egeberg M, Habermann A, et al. Involvement of ezrin/moesin in de novo actin assembly on phagosomal membranes. EMBO J. 2000; 19(2):199-212. (Clone-specific: Western blot). 참조 보기
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Mohler PJ, Kreda SM, Boucher RC, Sudol M, Stutts MJ, Milgram SL. Yes-associated protein 65 localizes p62(c-Yes) to the apical compartment of airway epithelia by association with EBP50. J Cell Biol. 1999; 147(4):879-890. (Clone-specific: Immunofluorescence). 참조 보기
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Perez OD, Kinoshita S, Hitoshi Y, et al. Activation of the PKB/AKT pathway by ICAM-2. Immunity. 2002; 16(1):51-65. (Clone-specific: Immunoprecipitation, Western blot). 참조 보기
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