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Western blot analysis of ALDH on A431 cell lysate. Lane 1: 1:500, lane 2: 1:1000, lane 3: 1:2000 dilution of anti-ALDH antibody.
Immunofluorescent staining of HepG2 cells with anti-ALDH.
BD Transduction Laboratories™ Purified Mouse Anti-ALDH
BD Transduction Laboratories™ Purified Mouse Anti-ALDH
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For Western blot: Please refer to http://www.bdbiosciences.com/support/resources/cell_biology/index.jsp
제품 고시
- Since applications vary, each investigator should titrate the reagent to obtain optimal results.
- Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
- Source of all serum proteins is from USDA inspected abattoirs located in the United States.
- Please refer to www.bdbiosciences.com/us/s/resources for technical protocols.
관련 제품
Aldehyde dehydrogenase (ALDH) is a ubiquitous enzyme located in nearly all mammalian tissues. It catalyzes the irreversible oxidation of a range of aliphatic and aromatic aldehydes to their corresponding carboxylic acids. There are multiple isoforms of ALDH which are subdivided into three classes. Class I includes the cytosolic isoforms. Class II includes the mitochondrial isoforms. Class III includes the microsomal, cytosolic tumor specific, and cytosolic dioxin-inducible forms. At least twelve human ALDH isoforms have been identified. Mutations of many of these proteins such as ALDH1, ALDH2, ALDH4, and ALDH10 have been implicated in multiple human metabolic disorders and clinical abnormalities. At the amino acid level, human ALDH isoforms exhibit a wide range of diversity (15% to about 80%). However, multiple protein regions have been highly conserved and are important for functional activities. A well-characterized member of the human ALDH family is ALDH1. It plays a major role in the biosynthesis of retinoic acid from retinol (vitamin A). Retinoic acid, the biologically active form of retinol, is a regulator of cellular proliferation, differentiation, and survival.
개발 참고 자료 (4)
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Greene WK, Bahn S, Masson N, Rabbitts TH. The T-cell oncogenic protein HOX11 activates Aldh1 expression in NIH 3T3 cells but represses its expression in mouse spleen development. Mol Cell Biol. 1998; 18(12):7030-7037. (Biology). 참조 보기
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Kathmann EC, Lipsky JJ. Cloning of a cDNA encoding a constitutively expressed rat liver cytosolic aldehyde dehydrogenase. Biochim Biophys Acta. 1997; 236(2):527-531. (Biology). 참조 보기
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Yoshida A, Rzhetsky A, Hsu LC, Chang C. Human aldehyde dehydrogenase gene family. J Biol Chem. 1998; 251(3):549-557. (Biology). 참조 보기
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Zhou JH, Hanna EY, Roberts D, Weber RS, Bell D. ALDH1 immunohistochemical expression and its significance in salivary adenoid cystic carcinoma. Head & Neck. 2012; 35(4):575-578. (Clone-specific: Immunohistochemistry). 참조 보기
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