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BD OptEIA™ Human C4a ELISA Kit
(RUO)Human C4a ELISA Kit
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설명
Activation of the classical or lectin, but not the alternate, complement pathways results in the production of the C4a anaphylatoxin. C4a has been shown to be a weak multi-functional proinflammatory mediator by increasing vascular permeability, and to be spasmogenic. In blood, plasma or serum, once formed, the nascent C4a anaphylatoxin is rapidly cleaved to the C4a-desArg form by the endogenous serum carboxypeptidase N enzyme. Thus, the quantitation of C4a-desArg in plasma or experimental samples should yield a reliable measurement of the level of classical complement pathway activation that has occurred in the test samples under investigation. C4a production in vivo may also signal activation of the classical or the lectin complement pathways in several autoimmune diseases including rheumatoid arthritis, lupus erythematosus, and acute glomerulonephritis as well as in early stages of organ transplant rejections. The BD OptEIATM Human C4a ELISA Kit is for the in vitro quantitative determination of human C4a and the human C4a-desArg in human EDTA plasma, serum and other biological samples. Components Quantity Antibody Coated Wells 1 plate (12 strips x 8 wells) Detection Antibody 15 mL Standards 3 vials, lyophilized Enzyme Concentrate (250x) 150
준비 및 보관
개발 참고 자료 (7)
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Ember JA., Jagels MA., Hugli TE. Characterization of complement anaphylatoxins and their biological responses. In: J.E. Volanakis and M.M. Frank, ed. The human complement system in health and disease. Marcel Dekker, Inc; 1998:241-284.
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Hugli, TE. Biochemistry and biology of anaphylatoxins. Complement . 1986; 3:108-110. (Biology).
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Matsushita, M and T Fujita. Activation of the classical complement pathway by mannose-binding protein in association with a novel C1s-like serine protease. J Exp Med. 1992; 176:1497-1502. (Biology).
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Pfeifer PH, JJ Brehms, M Brunson, and TE Hugli 2000. Plasma C3a and C4a levels in liver transplant recipients: a longitudinal study. Immunopharmacology. 2000; 46:163-174. (Biology).
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Pfeifer PH, Kawahara MS, Hugli TE. Possible mechanism for in vitro complement activation in blood and plasma samples: futhan/EDTA controls in vitro complement activation. Clin Chem. 1999; 45(8):1190-1199. (Biology). 참조 보기
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Porcel JM, J Ordi, A Castro-Salomo, et al. The value of complement activation products in the assessment of systemic lupus erythematosus flares. Clin Immunol lmmunopathol. 1995; 74(3):283-8. (Biology).
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Comparisons, where applicable, are made against older BD Technology, manual methods or are general performance claims. Comparisons are not made against non-BD technologies, unless otherwise noted.
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
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