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      CD81 (JS-81) BV605
      665134
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      $956.00
      EA (1 Each)
      100 Tests
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      Product Details
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      BD Horizon™
      TAPA1; Tetraspanin-28; Tspan-28; TSPAN28; CVID6; S5.7; M38
      Human
      Mouse IgG1, κ
      Flow cytometry
      V B070
      975
      ASR


      Data Sheets

      DownloadTechnical Data Sheet (TDS)DownloadSafety Data Sheet
      665134 Rev. 1
      Antibody Details
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      JS-81

      The CD81 antibody, clone JS-81, is derived from hybridization of P3/NS1/1-Ag4-1 mouse myeloma cells with spleen cells isolated from mice immunized with the Burkitt lymphoma cell line, Ramos.

      The CD81 antibody recognizes a 26-kilodalton (kDa) member of the tetraspanin family (TM4SF). The CD81 antigen is also known as TAPA-1.

      665134 Rev. 1
      Format Details
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      BV605
      The BD Horizon Brilliant Violet™ 605 (BV605) dye is part of the BD Horizon Brilliant Violet™ family of dyes. This tandem fluorochrome is comprised of a BV421 donor with an excitation maximum (Ex Max) of 407-nm and an acceptor dye with an emission maximum (Em Max) at 605-nm. BV605, driven by BD innovation, is designed to be excited by the violet laser (405-nm) and detected using an optical filter centered near 610-nm (e.g., a 610/20-nm bandpass filter). The acceptor dye can be excited by the yellow-green (561-nm) laser resulting in cross-laser excitation and fluorescence spillover. Please ensure that your instrument’s configurations (lasers and optical filters) are appropriate for this dye.
      altImg
      BV605
      Violet 405 nm
      407 nm
      605 nm
      665134 Rev.1
      Citations & References
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      Development References (6)

      1. Bradbury L, Tedder TF. CD81 (TAPA-1), a component of the CD19/CD21 signal transduction complex. In: Schlossman SF. Stuart F. Schlossman .. et al., ed. Leucocyte typing V : white cell differentiation antigens : proceedings of the fifth international workshop and conference held in Boston, USA, 3-7 November, 1993. Oxford: Oxford University Press; 1995:690-691.
      2. Carloni V, Mazzocca A, Ravichandran KS. Tetraspanin CD81 is linked to ERK/MAPKinase signaling by Shc in liver tumor cells. Oncogene. 2004; 23(8):1566-1574. View Reference
      3. Levy S, Todd SC, Maecker HT. CD81 (TAPA-1): a molecule involved in signal transduction and cell adhesion in the immune system. Annu Rev Immunol. 1998; 16:89-109. View Reference
      4. Mazzocca A, Sciammetta SC, Carloni V, et al. Binding of hepatitis C virus envelope protein E2 to CD81 up-regulates matrix metalloproteinase-2 in human hepatic stellate cells. J Biol Chem. 2005; 280(12):11329-11339. View Reference
      5. Sagi Y, Landrigan A, Levy R, Levy S. Complementary costimulation of human T-cell subpopulations by cluster of differentiation 28 (CD28) and CD81. Proc Natl Acad Sci U S A. 2012; 109(5):1613-1618. View Reference
      6. Tedder TF, Wagner N, Engel P. CD81 Workshop report. In: Schlossman SF. Stuart F. Schlossman .. et al., ed. Leucocyte typing V : white cell differentiation antigens : proceedings of the fifth international workshop and conference held in Boston, USA, 3-7 November, 1993. Oxford: Oxford University Press; 1995:684-688.
      View All (6) View Less
      665134 Rev. 1

      Please refer to Support Documents for Quality Certificates

       

      Global - Refer to manufacturer's instructions for use and related User Manuals and Technical data sheets before using this products as described

       

      Comparisons, where applicable, are made against older BD Technology, manual methods or are general performance claims.  Comparisons are not made against non-BD technologies, unless otherwise noted.

      For In Vitro Diagnostic Use.

       

      23-22942-00

      Analyte Specific Reagent. Analytical and performance characteristics are not established.

       

      Documents are subject to revision without notice. Please verify you have the correct revision of the document, and always refer back to BD's eIFU website for the latest and most up to date information.