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Mapping open chromatin regions at the single-cell level elucidates cell-to-cell variability in gene regulatory landscapes that drives cell fate decisions and responses to stimuli. Assay for transposase-accessible chromatin using sequencing (ATAC-seq) excels at this by providing an unbiased, genome-wide readout of chromatin accessibility with higher sensitivity than its predecessors. When combined with single-cell transcriptomic data from the same cells, the resulting multi-layer view enables direct associations of the gene regulatory chromatin state with gene expression output in each cell, affording even deeper mechanistic understanding of cell state in different conditions.

The BD Rhapsody ATAC-Seq Assays enable you to either generate highly reproducible open chromatin profiling data from single cells or perform a multiomic analysis of open chromatin accessibility and transcriptome of single cells in one experiment using the BD Rhapsody Single-Cell Analysis System.


Learn more from the BD Rhapsody ATAC-Seq Assay Brochure.



Validated on the new BD Rhapsody™ Enhanced Cell Capture Beads V3, BD Rhapsody™ ATAC-Seq Assays generate consistent, high-quality data across different samples and users and a wide range of cell inputs. Key features include:


  • High sensitivity and specificity across different experimental conditions
  • Capable of accommodating a wide range of cell inputs
  • Integrated epigenomic and transcriptomic characterization on the same cells
  • Compatibility with Custom BD® Nuclear Antibody-Oligonucleotide Conjugates


For Research Use Only. Not for use in diagnostic or therapeutic procedures.