Contract Research Services
In vitro techniques based on cDNA-expressed
enzymes, human tissue and cells, allow researchers to screen for drug-drug
interactions, metabolic stability, and bioavailablity early in the drug
development process. BD Biosciences is the leader in the development of
these novel systems and services for in vitro analysis of xenobiotic
(drug) metabolism. BD GentestSM
Contract Research Services combine our expertise and innovative
products to help you identify better drugs faster. We offer many contract
services that help the sponsor address important drug metabolism concerns
during the drug discovery and development processes. Many of these tests
can be performed in accordance with Good Laboratory Practices (GLP) regulations.
| Absorption/Transport |
- Cell Permeability
- PGP-ATPase Activity
- Transporter Efflux and Uptake
- Transporter Inhibition
|
Absorption and Transport Studies [ PDF
] |
| Metabolism |
- Metabolic Stability
- P450 Inhibition
- UGT Inhibition
- Reaction Phenotyping
- Hepatocyte Metabolism
|
Cytochrome P450 Reaction Phenotyping [ PDF
]
Inhibition of Cytochrome P450 and UGT [ PDF
]
Metabolic Stability [ PDF
] |
| Induction |
- Hepatocyte Models
- Ex Vivo
|
Cytochrome P450 Induction Studies in Human Hepatocytes
[ PDF
] |
| Physico-Chemical |
- Solubility
- Log P
- Protein Bindin
|
|
| Toxicity
|
- Hepatocyte Models
- Engineered Cell Lines
|
Toxicity Services [ PDF
] |
| Sponsor-Initiated
Protocols |
Call to discuss your project
|
|
Consult the ADME Experts via email or phone at 888.334.5229, ext. 0,
to discuss your needs. Customers outside the U.S. may reach us at 781.935.5115.
The complete FDA guidance document can be viewed on the FDA's Website.
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