Simplify Your Path to Standardized Leukemia and Lymphoma Workflow
BD OneFlow™ LST and BD OneFlow™ B-CLPD T1 are now FDA 510(k)-cleared in U.S. for identifying B-cell non-Hodgkin lymphoma (NHL), expanding access to standardized flow cytometry IVD diagnostics.
The BD OneFlow™ Solution is a clinically validated and scientific consortium backed1 testing system with standardized ready-to-use panels, protocols, and analysis principles for the identification and aid in diagnosis of B-cell non-Hodgkin's lymphoma including chronic lymphocytic leukemia (B-CLL).
Coming Soon: Less Complexity. More Confidence.
Streamline your workflow:
Reduce manual workflow steps by 95% to help improve laboratory efficiency and support faster turnaround times.
- Simplify everyday testing:
Ready-to-use, dried down reagents with at least 16 months shelf life and room-temperature storage with standardized protocols support optimized workflows.
- Deliver high-quality results:
Benefit from demonstrated 96.3% sensitivity and 98.2% specificity for the identification of B-CLL
- Build confidence in your results:
Rely on research-backed validation1, clinically relevant markers and robust assay performance.
Reagents:
BD OneFlow™ LST used in conjunction with BD OneFlow™ B-CLPD T1, can be used as an aid in diagnosis of B-cell non-Hodgkin’s lymphoma including B-cell chronic lymphocytic leukemia.
- BD OneFlow™ LST:
Markers in this reagent were chosen for their ability to separate normal lymphocytes into their major subpopulations and to differentiate hematologically abnormal B-cells from their normal counterparts, T-cells and NK-cells.
| Reagent | Laser | Violet | Blue | Red | |||||
| BD OneFlow™ LST | Fluorochrome | BD Horizon™ V450 | BD Horizon™ V500-C | FITC | PE | PerCP-Cy5.5 | PE-Cy7 | APC | APC-H7 |
| Marker | CD20 | CD45 | CD8 | CD56 | CD5 | CD19 | CD3 | CD38 | |
| CD4 | Igλ | Igκ | TCRγδ | ||||||
- BD OneFlow™ B-CLPD T1:
Markers in this reagent were chosen to work in conjunction with the antibodies in BD OneFlow™ LST to differentiate CLL from other types of non-Hodgkin’s lymphoma of mature B cells
| Reagent | Laser | Violet | Blue | Red | |||||
| BD OneFlow™ B-CLPD T1 | Fluorochrome | BD Horizon™ V450 | BD Horizon™ V500-C | FITC | PE | PerCP-Cy5.5 | PE-Cy7 | APC | APC-H7 |
| Marker | CD20 | CD45 | CD23 | CD10 | CD79b | CD19 | CD200 | CD43 | |
Clinical Instrument:
BD FACSLyric™ Flow Cytometer supports day to day stable performance for reproducible results and offers key automation features to streamline laboratory workflow
Software:
BD FACSuite™ Clinical Application assay installer standardizes acquisition and analysis with predefined templates to help support consistency of results
References
- van Dongen, J.J., Lhermitte, L., Bottcher, S., et al. EuroFlow antibody panels for standardized n-dimensional flow cytometric immunophenotyping of normal, reactive and malignant leukocytes. Leukemia. 2012; 26: 1908-1975.
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BD OneFlow™ LST and BD OneFlow™ B-CLPD T1 are for In Vitro Diagnostic Use with a BD FACSLyric™ Flow Cytometer.
The BD FACSLyric™ Flow Cytometer is a Class 1 Laser Product.
In the U.S., the BD FACSLyric™ Flow Cytometer is for In Vitro Diagnostic Use with BD FACSuite™ Clinical Application for up to eight colors.
In the U.S., the BD FACSLyric™ Flow Cytometer is for Research Use Only with BD FACSuite™ Application for up to 12 colors. Not for use in diagnostic or therapeutic procedures.