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ISCT 2025 Panel Discussions

Watch the clips from the ISCT panel discussion featuring top researchers and industry experts sharing best practices for implementing new technologies in cell therapy R&D. Learn how to enhance precision, efficiency, and scalability in developing next-generation therapies and optimizing manufacturing workflows. Key topics discussed include advanced flow cytometry tools, standardization for QC, and strategic partnerships to accelerate progress.

The Most Interesting Questions and Opportunities in Cell Therapy Development

Studying Antigen Escape in B-all using the BD Rhapsody™ System


Speaker: Pablo Domizi, PhD, Stanford University


Learn how the BD Rhapsody™ enabled:
 

  • The role of IKAROS in antigen escape
  • Discovery of IKAROS levels being associated with resistance to CD19/CD22-targetedtherapies
  • Orthogonal validation using CyTOF confirmed findings

50-Color Spectral Cytometry Panel to Find Correlation of ICANS in Clinical Trial Samples


Speaker: Evan Newel, PhD, Fred Hutch Cancer Center

Learn how high parameter spectral flow cytometry panels were used for:​
 

  • Multi-modal profiling: serum analysis, scRNA/CITE-seq, spectral flow, whole blood profiling
  • Whole blood immuno-profiling and immune-module analysis linked to clinical outcomes (e.g. ICANS)
  • Network analysis of cytokines, granulocytes, and mononuclear cells associated with ICANS severity​

See How the BD FACSDiscover ™ A8 Cell Analyzer Can Enable Deeper Characterization During CAR Cell Development


Speaker: Aaron Tyznik, PhD, BD Biosciences


Explore how the BD FACSDiscover™ S8 and A8 Instruments with real-time imaging flow cytometery can enable deeper characterization for cell therapy products with applications such as: ​
 

  • Visualization of cell interactions (e.g., synaptic vs. coincident doublets). ​
  • Phagocytosis, ​
  • Tumor cell killing, etc​

Automated Analysis with BD Elastigate™ Software Aboard the BD FACSLyric™ Cell Analyzer


Speaker: Sahul Patel, MSC, Novartis


Meeting standardization requirements in the GMP environment with: 
 

  • Consistent results across BD FACSLyric™ instruments for cell therapy QC assays
  • Automated analysis using BD ElastiGate™ with high accuracy (F1 scores >0.93) across various applications including cell therapy QC, TIL phenotyping, and drug screening

How GMP-Clinical Requirements Can Influence Upstream Discovery and Development Work


Watch the panelists discuss how GMP and clinical requirements can be proactively integrated during early discovery and development to streamline the translation and accelerate the clinical advancement of cell therapies.​

Hear the Panelists Discuss Their Thoughts on the Most Exciting Frontiers of Cell Therapy Development Using BD Technology