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      PE Rat anti-Human CD267
      PE Rat anti-Human CD267
      Flow cytometric analysis of PE-conjugated anti-Human CD267 in human peripheral blood lymphocytes.   Human peripheral blood lymphocytes were stained with APC-conjugated anti-human CD19 (Clone HIB19; Cat. No. 555415) and PE-conjugated anti-human CD267 antibody (Clone 1A1-K21-M22, Cat. No. 558414; right panel) or PE -conjugated rat IgG2a (Clone R35-95, Cat. No. 553930; left panel). Flow cytometry was performed on a BD™ FACSCalibur flow cytometry system and the dot plots were derived from the gated events based on light scattering characteristics of lysed whole blood.
      PE Rat anti-Human CD267
      Flow cytometric analysis of PE-conjugated anti-Human CD267 in human peripheral blood lymphocytes.   Human peripheral blood lymphocytes were stained with APC-conjugated anti-human CD19 (Clone HIB19; Cat. No. 555415) and PE-conjugated anti-human CD267 antibody (Clone 1A1-K21-M22, Cat. No. 558414; right panel) or PE -conjugated rat IgG2a (Clone R35-95, Cat. No. 553930; left panel). Flow cytometry was performed on a BD™ FACSCalibur flow cytometry system and the dot plots were derived from the gated events based on light scattering characteristics of lysed whole blood.
      Product Details
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      BD Pharmingen™
      TACI; TNFRSF13B; Tumor necrosis factor receptor 13B; TNFRSF14B2; CVID2
      Human (QC Testing)
      Rat IgG2a, κ
      Human TACI-transfected RBL cells
      Flow cytometry (Routinely Tested)
      0.2 mg/ml
      VIII 80683
      23495
      AB_647196
      Aqueous buffered solution containing ≤0.09% sodium azide.
      RUO


      Preparation And Storage

      The antibody was conjugated with R-PE under optimum conditions, and unconjugated antibody and free PE were removed. Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
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      Product Notices

      1. Please refer to www.bdbiosciences.com/us/s/resources for technical protocols.
      2. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
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      558414 Rev. 1
      Antibody Details
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      1A1-K21-M22

      The 1A1-K21-M22 monoclonal antibody specifically binds to CD267 which is also known as TACI (Transmembrane Activator and CAML Interactor). CD267 is a member of the of the Tumor Necrosis Factor Receptor (TNFR) Superfamily and is encoded by the TNFRSF13B gene. This 32 kDa type III transmembrane protein receptor binds to the ligands, BAFF (TNFSF13B/BLyS/CD257) and APRIL (TNFSF13/CD256). Ligand-bound CD267 transduces signals leading to the activation of transcription factors including NFAT, AP1, and NF-kappa-B. CD267 is expressed most notably on maturing subsets of B cells and myeloma cells. In CD267 deficient mice, B cell numbers are increased and mice develop autoimmune disorders suggesting that CD267 plays an important role in the regulation of B cell homeostasis.

      558414 Rev. 1
      Format Details
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      PE
      R-Phycoerythrin (PE), is part of the BD family of Phycobiliprotein dyes. This fluorochrome is a multimeric fluorescent phycobiliprotein with excitation maximum (Ex Max) of 496 nm and 566 nm and an emission maximum (Em Max) at 576 nm. PE is designed to be excited by the Blue (488 nm), Green (532 nm) and Yellow-Green (561 nm) lasers and detected using an optical filter centered near 575 nm (e.g., a 575/26-nm bandpass filter). As PE is excited by multiple lasers, this can result in cross-laser excitation and fluorescence spillover on instruments with various combinations of Blue, Green, and Yellow-Green lasers. Please ensure that your instrument’s configurations (lasers and optical filters) are appropriate for this dye.
      altImg
      PE
      Yellow-Green 488 nm, 532 nm, 561 nm
      496 nm, 566 nm
      576 nm
      558414 Rev.1
      Citations & References
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      Development References (3)

      1. Ng LG, Sutherland AP, Newton R, et al. B cell-activating factor belonging to the TNF family (BAFF)-R is the principal BAFF receptor facilitating BAFF costimulation of circulating T and B cells.. J Immunol. 2004; 173(2):807-17. (Biology). View Reference
      2. O'Connor BP, Raman VS, Erickson LD, et al. BCMA is essential for the survival of long-lived bone marrow plasma cells.. J Exp Med. 2004; 199(1):91-8. (Biology). View Reference
      3. Seshasayee D, Valdez P, Yan M, Dixit VM, Tumas D, Grewal IS.. Loss of TACI causes fatal lymphoproliferation and autoimmunity, establishing TACI as an inhibitory BLyS receptor. Immunity. 2003; 18(2):279-288. (Biology). View Reference
      558414 Rev. 1

      Please refer to Support Documents for Quality Certificates


      Global - Refer to manufacturer's instructions for use and related User Manuals and Technical data sheets before using this products as described


      Comparisons, where applicable, are made against older BD Technology, manual methods or are general performance claims.  Comparisons are not made against non-BD technologies, unless otherwise noted.

      For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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