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      Anti-HER-2/neu FITC
      Product Details
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      BD™
      HER2; NEU; ERBB2; p185HER2; erb-b2 receptor tyrosine kinase 2; CD340
      Human
      Mouse BALB/c IgG1
      SKBR3 human breast carcinoma cells
      Flow cytometry
      5 μg/mL
      20 μL
      2064
      Phosphate buffered saline with gelatin and 0.1% sodium azide.
      ASR


      Preparation And Storage

      Vials should be stored at 2° to 8°C. Conjugated forms should not be frozen and should be protected from prolonged exposure to light. Each reagent is stable for the period shown on the bottle label when stored as directed.

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      340880 Rev. 1
      Antibody Details
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      NEU 24.7

      Anti–HER-2/neu, clone Neu 24.7, is derived from the fusion of NSO myeloma cells with spleen cells from BALB/c mice injected with living SKBR3 human breast carcinoma cells.

      Anti–HER-2/neu recognizes a single protein of 185 kdaltons from HER-2 transfected cells.

      340880 Rev. 1
      Format Details
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      FITC
      Fluorescein (FITC) is part of the BD blue family of dyes. This is a small organic fluorochrome with an excitation maximum (Ex Max) at 494-nm and an emission maximum (Em Max) at 518-nm. FITC is designed to be excited by the Blue laser (488-nm) and detected using an optical filter centered near 520 nm (e.g., a 530/30-nm bandpass filter). Please ensure that your instrument’s configurations (lasers and optical filters) are appropriate for this dye.
      altImg
      FITC
      Blue 488 nm
      494 nm
      518 nm
      340880 Rev.1
      Citations & References
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      Development References (3)

      1. Fendly BM, Kotts C, Vetterlein D, et al. The extracellular domain of HER2/neu is a potential immunogen for active specific immunotherapy of breast cancer. J Biol Response Mod. 1990; 9(5):449-455. (Biology). View Reference
      2. Stancovski I, Hurwitz E, Leitner O, Ullrich A, Yarden Y, Sela M. Mechanistic aspects of the opposing effects of monoclonal antibodies to the ERBB2 receptor on tumor growth.. Proc Natl Acad Sci USA. 1991; 88(19):8691-5. (Biology). View Reference
      3. Szollosi J, Balazs M, Feuerstein BG, Benz CC, Waldman FM. ERBB-2 (HER2/neu) gene copy number, p185HER-2 overexpression, and intratumor heterogeneity in human breast cancer. Cancer Res. 1995; 55(22):5400-5407. (Biology). View Reference
      340880 Rev. 1

      Please refer to Support Documents for Quality Certificates


      Global - Refer to manufacturer's instructions for use and related User Manuals and Technical data sheets before using this products as described


      Comparisons, where applicable, are made against older BD Technology, manual methods or are general performance claims.  Comparisons are not made against non-BD technologies, unless otherwise noted.

      Analyte Specific Reagent. Analytical and performance characteristics are not established.

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