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Purified Mouse Anti-STRAP
Product Details
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BD Transduction Laboratories™
Rat (QC Testing), Human (Tested in Development)
Mouse IgG1
Mouse STRAP aa. 42-154
Western blot (Routinely Tested), Immunofluorescence (Tested During Development)
39 kDa
250 µg/ml
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.

Preparation And Storage

The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography. Store undiluted at -20°C.

Recommended Assay Procedures

Western blot: Please refer to

Product Notices

  1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
  2. Please refer to for technical protocols.
  3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
  4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
611346 Rev. 1
Antibody Details
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The transforming growth factor β (TGF-β) family of cytokines plays diverse and important roles in growth, development, and differentiation. Three high affinity TGF-β receptor types have been characterized. Both type I and type II receptors are type I transmembrane proteins which contain a Ser/Thr-kinase in their cytosolic domains. Type III receptor, also known as betaglycan, has no cytosolic signaling motif and functions in the presentation of TGF-β to the type I and type II receptors. The cytosolic domain kinase of the type I receptor is thought to be transphosphorylated by the corresponding kinase of the type II receptor, leading to activation of downstream substrates. Ser/Thr receptor associated protein (STRAP) contains six WD domains, which are characteristic of signal transduction proteins. STRAP can associate with both TGF-βI and TGF-βII receptors and overexpression of STRAP leads to inhibition of TGF-β-dependent transcriptional activation. STRAP is expressed ubiquitously in species ranging from yeast to human. Thus, STRAP may be an important element of TGF-β signal transduction pathways in a variety of tissues and species.

611346 Rev. 1
Format Details
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Tissue culture supernatant is purified by either protein A/G or affinity purification methods. Both methods yield antibody in solution that is free of most other soluble proteins, lipids, etc. This format provides pure antibody that is suitable for a number of downstream applications including: secondary labeling for flow cytometry or microscopy, ELISA, Western blot, etc.
611346 Rev.1
Citations & References
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Development References (1)

  1. Datta PK, Chytil A, Gorska AE, Moses HL. Identification of STRAP, a novel WD domain protein in transforming growth factor-beta signaling. J Biol Chem. 1998; 273(52):34671-34674. (Biology). View Reference
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Please refer to Support Documents for Quality Certificates

Global - Refer to manufacturer's instructions for use and related User Manuals and Technical data sheets before using this products as described

Comparisons, where applicable, are made against older BD Technology, manual methods or are general performance claims.  Comparisons are not made against non-BD technologies, unless otherwise noted.

For Research Use Only. Not for use in diagnostic or therapeutic procedures.