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Single-cell multiomics experiments are key to unlocking the secrets of cancer and paving the way for better treatments. Download our latest application ebook, Advancing immuno-oncology through single-cell multiomics, to see how single-cell multiomics, the BD Rhapsody™ System and cell sorting can be used to gain important insights into cancer immunology.
We look at chronic lymphocytic leukemia (CLL), the most prevalent form of leukemia in adults. We navigate the intricate landscape of CLL pathogenesis, where bulk RNA-seq studies, though insightful, fall short in deciphering intratumoral heterogeneity. Harnessing the power of single-cell RNA sequencing via the BD Rhapsody™ System, this chapter sheds light on disease-specific signatures, offering a more granular view.
We deal with B cell malignancies, a dynamic arena characterized by the interplay between malignant cells and the TME. The focus centers on the B and T lymphocyte attenuator (BTLA) within a murine model ofB cell lymphoma. Through a high-throughput sorting strategy and single-cell multiomic analysis using the BD Rhapsody™ System, this chapter reveals the interplay between neoplastic cells and their surroundings.
We delve into hematopoiesis, a choreographed process that underlies the generation of diverse blood cell lineages. In the shadow of cancer, the orchestration falters, giving rise to immunosuppressive myeloid cells. This chapter unravels the mechanisms driving tumor-induced perturbations in hematopoiesis. It examines sorted hematopoietic stem and progenitor cell (HSPC) populations through the lens of a melanoma mouse model, providing a comprehensive understanding of the alterations induced by the tumor.
We unveil critical roles of T and B cells in anti-tumor activity, spotlighting their unique antigen receptors and clonotypes. By studying the T cell receptor (TCR) and B cell receptor (BCR) repertoire in the tumor microenvironment, this chapter exposes the intricate dynamics governing immune responses to cancer. Using an mc38 syngeneic carcinoma tumor model, this chapter showcases the power of the BD Rhapsody™ System in unraveling the heterogeneity of T and B cells and their clonotype diversity.
We highlight advances in single-cell multiomics that allow high-resolution functional characterization of intratumoral immune cells. In-depth dissection of the immune composition of the tumor microenvironment using both flow cytometry and the BD Rhapsody™ System allows examination of the expression of mRNA and surface protein markers at single-cell resolution. Understanding the transcriptional and proteomic phenotypes of tumor infiltrating leukocytes is helpful for development of novel immunomodulatory strategies for cancer.
Download the E-Book: Advancing Immuno-Oncology through Single-Cell Multiomics
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