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Single-cell Genomic Approaches for Developing the Next Generation of Immunotherapies
Developments in single-cell genomics, proteomics, computing, and antibody engineering have enabled significant progress in drug development. See how and read now.
BD Joins Consortium to Accelerate Technology Development and Lower the Costs in Cell and Gene Therapy Manufacturing
Wouldn’t it be wonderful if we could reach a point in medical history where disease can be cured without drugs? A step in that direction has been taken this year by BD, which has joined a consortium of over 20 companies with the aim of pooling knowledge in cell and gene therapy.
Bifidobacteria-Mediated Immune System Imprinting Early In Life
The lack of bifidobacteri, is associated with systemic inflammation and immune dysregulation in early life.
Antigen-specific B cells and chronic infection: The OMIP panel
Originating in the bone marrow, antigen-specific B cells are critical in infection prevention and control through antibody production, professional antigen presentation and cytokine secretion.
An Optimized 50-Color Flow Cytometry Panel for Analysis of T Cells and Dendritic Cells
Immune cell analysis at the periphery and at the tissue level has provided valuable insights into our understanding of how immune cells differentiate and what roles they play, as well as how they function in various diseases.
A Method to Study Tissue Microenvironments at Single-Cell Resolution
Spatial transcriptomics is a rapidly evolving field aiming to capture transcriptomic features and spatial relationships of cells within tissues.
A Novel Multiplex Flow Proxy Assay for the Simultaneous Measurement of Multiple Biomarkers
Combining the analysis of protein biomarkers to genome-wide expression profiling at the single-cell level provides deeper scientific insights than previously possible.
Comparison of the human tumor microenvironment with non-malignant inflamed tissue to understand tumor immune alterations
A hallmark of immune-infiltrate human tumor tissues is the presence of an inflammatory microenvironment; however, it is not well understood which immune cell subsets and signaling pathways are unique to the human tumor microenvironment compared to those from general inflammatory processes.
Early Life Imprinting and Immune System Responses to Bifidobacteria Colonization
There is mounting evidence to suggest that during the first three months of life the infant gut microbiome is crucial for immune development.
Using Flow Cytometry and Single-Cell Multiomics for Analyzing COVID-19 Immune Responses
The human immune system exerts coordinated responses capable of overcoming a broad spectrum of pathogenic challenges, including viral infections. Understanding the nature and sequence of these responses paves the way for targeting specific cells for further translational research.
Immunotyping of Natural Killer (NK) Cells in COVID-19 Patients Using High-Parameter Flow Cytometry
SARS-CoV-2 infection elicits a spectrum of immune responses, activating both the innate and adaptive immune systems. Whether these immune responses are targeted and controlled or misdirected and uncontrolled could determine the outcome of the disease.
High-Parameter Flow Cytometry for Deep Immune Profiling of COVID-19 Patients
The SARS-CoV-2 virus infection presents a range of clinical manifestations, ranging from mild or no symptoms to moderate to severe respiratory illnesses, such as ARDS (acute respiratory-distress syndrome) and multiorgan failure, to death.