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CD38 Antibodies
Explore multiple clones against CD38 available for ASR, RUO, and RUO (GMP) use. These antibodies can be used for applications such as flow cytometry, Western blot and Cite-seq against Mouse, Rat and Human targets. Our anti-CD38 antibodies were developed in Mouse and Rat and have Rat IgG2a κ, and Mouse IgG1 κ isotypes. Our CD38-specific antibodies have been used in over 500 articles in peer-reviewed journals. Review over 50 figures from product development to select the best reagents for your needs.
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Entrez Gene
Description: The protein encoded by this gene is a non-lineage-restricted, type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5'-diphosphate-ribose, an intracellular calcium ion mobilizing messenger. The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein. This protein has an N-terminal cytoplasmic tail, a single membrane-spanning domain, and a C-terminal extracellular region with four N-glycosylation sites. Crystal structure analysis demonstrates that the functional molecule is a dimer, with the central portion containing the catalytic site. It is used as a prognostic marker for patients with chronic lymphocytic leukemia. Alternative splicing results in multiple transcript variants.
Description: This gene encodes a non-lineage-restricted, type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5'-diphosphate-ribose, an intracellular calcium ion mobilizing messenger. The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein. This protein has an N-terminal cytoplasmic tail, a single membrane-spanning domain, and a C-terminal extracellular region with four N-glycosylation sites. Knockout mice deficient for this gene display altered humoral immune responses. In addition, knockout mice exhibit higher locomotor activity and defects in nurturing and social behaviors.
UniProt
Function: Synthesizes cyclic ADP-ribose (cADPR), a second messenger for glucose-induced insulin secretion. Synthesizes the Ca2+ mobilizer nicotinate-adenine dinucleotide phosphate, NAADP+, from 2'-phospho-cADPR and nicotinic acid, as well as from NADP+ and nicotinic acid. At both pH 5.0 and pH 7.4 preferentially transforms 2'-phospho-cADPR into NAADP+, while preferentially cleaving NADP+ to cADPR and ADPRP rather than into NADDP+ . Has cADPR hydrolase activity .
Molecular Function: Hydrolase, Receptor, Transferase
Subcellular location: Cell surface, membrane
kDa: 34
Function: Synthesizes the second messengers cyclic ADP-ribose (cADPR) and nicotinate-adenine dinucleotide phosphate (NAADP), the former a second messenger for glucose-induced insulin secretion, the latter a Ca2+ mobilizer. Also has cADPR hydrolase activity
Molecular Function: Hydrolase, Transferase
Subcellular location: Membrane
Protein Family: ADP-ribosyl cyclase family
kDa: 34
AKA
I-19, ADPRC 1, Cd38-rs12'-phospho-ADP-ribosyl cyclase, 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase, 2'-phospho-cyclic-ADP-ribose transferase, ADP-ribosyl cyclase 1 (ADPRC 1), Cyclic ADP-ribose hydrolase 1 (cADPR hydrolase 1), NIM-R5 antigen, ADPRC1, cADPR1, ADPRC 12'-phospho-ADP-ribosyl cyclase, 2, T1
CD38 Antibody Products









For Research Use Only. Not for use in diagnostic or therapeutic procedures.