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Preparation And Storage
Product Notices
- Since applications vary, each investigator should titrate the reagent to obtain optimal results.
- An isotype control should be used at the same concentration as the antibody of interest.
- Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
- For fluorochrome spectra and suitable instrument settings, please refer to our Multicolor Flow Cytometry web page at www.bdbiosciences.com/colors.
- Please refer to www.bdbiosciences.com/us/s/resources for technical protocols.
Companion Products
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The M3-3D9 (SN1a) monoclonal antibody specifically recognizes CD231 which is also known as T-cell acute lymphoblastic leukemia-associated antigen 1 (TALLA-1) or Membrane component chromosome X surface marker 1 (MXS1). CD231 (TALLA-1) consists of four transmembrane domains, a short extracellular loop, a short intracellular loop, a longer extracellular loop, and short N- and C-terminal cytoplasmic tails. This ~150 kDa multi-pass transmembrane glycoprotein is encoded by TSPAN7 (Tetraspanin 7). It belongs to the tetraspanin superfamily (TM4SF) and is likewise known as Transmembrane 4 superfamily member 2 (TM4SF2). CD231 (TALLA-1) may play roles in integrin-mediated migration and the control of neurite outgrowth. It is expressed on the surface of T-cell type acute lymphoblastic leukemia (T-ALL) cells, neuroblastoma cells, and normal brain neurons. CD231 (TALLA-1) gene mutations are associated with X-linked mental retardation.
Development References (8)
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Abidi FE, Holinski-Feder E, Rittinger O, et al. A novel 2 bp deletion in the TM4SF2 gene is associated with MRX58. J Med Genet. 2002; 39(6):430-433. (Biology). View Reference
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Azorsa DO, Horejsi V. CD231 (TALLA-1) Summary and Workshop report. In: Mason D. David Mason .. et al., ed. Leucocyte typing VII : white cell differentiation antigens : proceedings of the Seventh International Workshop and Conference held in Harrogate, United Kingdom. Oxford: Oxford University Press; 202:509-510.
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Bassani S, Cingolani LA, Valnegri P, et al. The X-linked intellectual disability protein TSPAN7 regulates excitatory synapse development and AMPAR trafficking. Neuron. 2012; 73(6):1143-1158. (Biology). View Reference
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Castellví-Bel S, Milà M. Genes responsible for nonspecific mental retardation.. Mol Genet Metab. 2001; 72(2):104-8. (Biology). View Reference
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Cheong CM, Chow AW, Fitter S, et al. Tetraspanin 7 (TSPAN7) expression is upregulated in multiple myeloma patients and inhibits myeloma tumour development in vivo. Exp Cell Res. 2015; 332(1):24-38. (Biology). View Reference
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Matsuzaki H, Seon BK. Molecular nature of a cell membrane antigen specific for human T-cell acute lymphoblastic leukemia. Cancer Res. 1987; 47(16):4283-4286. (Immunogen: Blocking, Radioimmunoassay). View Reference
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McLaughlin KA, Richardson CC, Ravishankar A, et al. Identification of Tetraspanin-7 as a Target of Autoantibodies in Type 1 Diabetes. Diabetes. 2016; 65(6):1690-8. (Biology). View Reference
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Seon BK, Negoro S, Barcos MP. Monoclonal antibody that defines a unique human T-cell leukemia antigen.. Proc Natl Acad Sci USA. 1983; 80(3):845-9. (Biology). View Reference
Please refer to Support Documents for Quality Certificates
Global - Refer to manufacturer's instructions for use and related User Manuals and Technical data sheets before using this products as described
Comparisons, where applicable, are made against older BD Technology, manual methods or are general performance claims. Comparisons are not made against non-BD technologies, unless otherwise noted.
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
