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Purified Mouse Anti-LRP
Product Details
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BD Transduction Laboratories™
Human (QC Testing), Dog, Rabbit, Cow (Tested in Development)
Mouse IgG1
Human LRP aa. 403-592
Western blot (Routinely Tested), Immunofluorescence, Immunohistochemistry, Immunoprecipitation (Tested During Development)
110 kDa
250 µg/ml
AB_397875
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
RUO


Preparation And Storage

The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography. Store undiluted at -20°C.

Product Notices

  1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
  2. Please refer to www.bdbiosciences.com/us/s/resources for technical protocols.
  3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
  4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
610512 Rev. 1
Antibody Details
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42/LRP

Drugs that selectively attack dividing cells are often used in cancer therapy. However, small cell populations do not die, but develop resistance to a variety of toxic drugs. Multidrug resistance is achieved by gene amplification of specific membrane-bound transport ATPases that shuttle the drugs out of cells. Some multidrug-resistant cancer cells express a protein of 110 kDa named LRP (Lung Resistance-related Protein). LRP expression might be an indicator of prognosis after chemotherapy in acute myeloid leukemia and ovarian carcinoma. The LRP gene encodes a protein of 896 amino acids with significant homology to the major vault protein from Dictyostelium discoideum. Although ubiquitously expressed, LRP is most abundant in epithelial cells.

610512 Rev. 1
Format Details
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Purified
Tissue culture supernatant is purified by either protein A/G or affinity purification methods. Both methods yield antibody in solution that is free of most other soluble proteins, lipids, etc. This format provides pure antibody that is suitable for a number of downstream applications including: secondary labeling for flow cytometry or microscopy, ELISA, Western blot, etc.
Purified
610512 Rev.1
Citations & References
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Development References (4)

  1. Kickhoefer VA, Rome LH. The sequence of a cDNA encoding the major vault protein from Rattus norvegicus. Gene. 1994; 151(1-2):257-260. (Biology). View Reference
  2. List AF, Spier CS, Grogan TM. Overexpression of the major vault transporter protein lung-resistance protein predicts treatment outcome in acute myeloid leukemia. Blood. 1996; 87(6):2464-2469. (Biology). View Reference
  3. Rybarova S, Batekova M, Hodorova I. Immunohistochemical detection of LRP protein in the normal human lung. Bratisl Lek Listy. 2002; 102(2):66-72. (Clone-specific: Immunohistochemistry). View Reference
  4. Scheffer GL, Wijngaard PL, Flens MJ. The drug resistance-related protein LRP is the human major vault protein. Nat Med. 1995; 1(6):578-582. (Biology). View Reference
View All (4) View Less
610512 Rev. 1

Please refer to Support Documents for Quality Certificates


Global - Refer to manufacturer's instructions for use and related User Manuals and Technical data sheets before using this products as described


Comparisons, where applicable, are made against older BD Technology, manual methods or are general performance claims.  Comparisons are not made against non-BD technologies, unless otherwise noted.

Non-IVD products are For Research Use Only. Not for use in diagnostic or therapeutic procedures.

 

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