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PE Mouse Anti-Human CD7
Regulatory Status Legend
Any use of products other than the permitted use without the express written authorization of Becton, Dickinson and Company is strictly prohibited.
Preparation And Storage
Store vials at 2°C–8°C. Conjugated forms should not be frozen. Protect from exposure to light. Each reagent is stable until the expiration date shown on the bottle label when stored as directed.
The CD7 antibody, clone M-T701, is derived from the hybridization of mouse P3-X63-Ag8.653 cells with spleen cells from BALB/c mice immunized with P-CLL and Jurkat cells. The CD7 antibody recognizes a 40-kilodalton (kDa) type I transmembrane glycoprotein that is a member of the immunoglobulin superfamily (IgSF). The CD7 antigen is also known as Leu-9, TP41, Tp40, GP40, and T-cell leukemia antigen.
Development References (20)
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Carrel S, Salvi S, Rafti F, Favrot M, Rapin C, Sekaly RP Direct involvement of CD7 (gp40) in activation of TcR γ/δ+ T cells. Eur J Immunol. 1991; 1195-1200. (Biology).
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Centers for Disease Control. Update: universal precautions for prevention of transmission of human immunodeficiency virus, hepatitis B virus, and other bloodborne pathogens in healthcare settings. MMWR. 1988; 37:377-388. (Biology).
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Clinical and Laboratory Standards Institute. 2005. (Biology).
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Foon KA, Todd RF. Immunologic classification of leukemia and lymphoma.. Blood. 1986; 68(1):1-31. (Biology). View Reference
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Grümayer ER, Griesinger F, Hummell DS, Brunning RD, Kersey JH. Identification of novel B-lineage cells in human fetal bone marrow that coexpress CD7. Blood. 1991; 77:64-68. (Biology).
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Lam GK, Liao HX, Xue Y, et al. Expression of the CD7 ligand K-12 in human thymic epithelial cells: regulation by IFN-γ. J Clin Immunol. 2005; 25:41-49. (Biology).
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Lazarovits AI, Karsh J. Decreased expression of CD7 occurs in rheumatoid arthritis. Clin Exp Immunol. 1988; 72:470-475. (Biology).
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Lazarovits AI, White MJ, Karsh J. CD7– T cells in rheumatoid arthritis. Arthritis Rheum. 1992; 35:615-624. (Biology).
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Link M, Warnke R, Finlay J, et al. A single monoclonal antibody identifies T-cell lineage of childhood lymphoid malignancies. Blood. 1983; 62:722-728. (Biology).
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Lyman SD, Escobar S, Rousseau AM, Armstrong A, Fanslow WC. Identification of CD7 as a cognate of the human K12 (SECTM1) protein. J Biol Chem. 2000; 275:3431-3437. (Biology).
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Pace KE, Hahn HP, Pang M, Nguyen JT, Baum LG. CD7 delivers a pro-apoptotic signal during galectin-1-induced T cell death. J Immunol. 2000; 165:2331-2334. (Biology).
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Palker TJ, Scearce RM, Hensley LL, Ho W, Haynes BF. Comparison of the CD7 (3A1) group of T cell workshop antibodies. In: Reinherz EL, Haynes BF, Nadler LM, Bernstein ID, ed. Leukocyte Typing II. Human T Lymphocytes. New York, NY: Springer-Verlag; 1986:303-313.
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Picker LJ, Weiss LM, Medeiros LJ, Wood GS, Warnke RA. Immunophenotypic criteria for the diagnosis of non-Hodgkin's lymphoma.. Am J Pathol. 1987; 128(1):181-201. (Biology). View Reference
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Rabinowich H, Lin WC, Herberman RB, Whiteside TL. Signaling via CD7 molecules on human NK cells. Induction of tyrosine phosphorylation and β 1 integrin-mediated adhesion to fibronectin. J Immunol. 1994; 153:3504-3513. (Biology).
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Rabinowich H, Pricop L, Herberman RB, Whiteside TL. Expression and function of CD7 molecule on human natural killer cells. J Immunol. 1994; 152(2):517-526. (Biology). View Reference
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Reiter C. Knapp W, Dörken B, Gilks WR, et al, ed. Leucocyte Typing IV: White Cell Differentiation Antigens. New York, NY: Oxford University Press; 1989:341-342.
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Weiss LM, Crabtree GS, Rouse RV, Warnke RA. Morphologic and immunologic characterization of 50 peripheral T-cell lymphomas. Am J Pathol. 1985; 118:316-324. (Biology).
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Weiss LM, Wood GS, Warnke RA. Immunophenotypic differences between dermatopathic lymphadenopathy and lymph node involvement in mycosis fungoides. Am J Pathol. 1985; 120:179-185. (Biology).
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Williams AF, Barclay AN. The immunoglobulin superfamily—domains for cell surface recognition. Ann Rev Immunol. 1988; 6:381-405. (Biology).
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Wood GS, Abel EA, Hoppe RT, Warnke RA. Leu-8 and Leu-9 antigen phenotypes: immunologic criteria for the distinction of mycosis fungoides from cutaneous inflammation. J Am Acad Dermatol. 1986; 14:1006-1013. (Biology).
Please refer to Support Documents for Quality Certificates
Global - Refer to manufacturer's instructions for use and related User Manuals and Technical data sheets before using this products as described
Comparisons, where applicable, are made against older BD Technology, manual methods or are general performance claims. Comparisons are not made against non-BD technologies, unless otherwise noted.
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
Although not required, these products are manufactured in accordance with Good Manufacturing Practices.