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PE Mouse Anti-Human CD7
Product Details
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BD™
GP40; LEU-9; T-cell leukemia antigen; Tp40; TP41
Human
Mouse BALB/c IgG1, κ
P-CLL and Jurkat Cells
Flow cytometry
12.5 μg/mL
20 μL
IV T163
924
Phosphate buffered saline with gelatin and 0.1% sodium azide.
RUO (GMP)


Preparation And Storage

Store vials at 2°C–8°C. Conjugated forms should not be frozen. Protect from exposure to light. Each reagent is stable until the expiration date shown on the bottle label when stored as directed.

340581 Rev. 1
Antibody Details
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M-T701

The CD7 antibody, clone M-T701, is derived from the hybridization of mouse P3-X63-Ag8.653 cells with spleen cells from BALB/c mice immunized with P-CLL and Jurkat cells.

The CD7 antibody recognizes a 40-kilodalton (kDa) type I transmembrane glycoprotein that is a member of the immunoglobulin superfamily (IgSF). The CD7 antigen is also known as Leu-9, TP41, Tp40, GP40, and T-cell leukemia antigen.

340581 Rev. 1
Format Details
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PE
R-Phycoerythrin (PE), is part of the BD family of Phycobiliprotein dyes. This fluorochrome is a multimeric fluorescent phycobiliprotein with excitation maximum (Ex Max) of 496 nm and 566 nm and an emission maximum (Em Max) at 576 nm. PE is designed to be excited by the Blue (488 nm), Green (532 nm) and Yellow-Green (561 nm) lasers and detected using an optical filter centered near 575 nm (e.g., a 575/26-nm bandpass filter). As PE is excited by multiple lasers, this can result in cross-laser excitation and fluorescence spillover on instruments with various combinations of Blue, Green, and Yellow-Green lasers. Please ensure that your instrument’s configurations (lasers and optical filters) are appropriate for this dye.
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PE
Yellow-Green 488 nm, 532 nm, 561 nm
496 nm, 566 nm
576 nm
340581 Rev.1
Citations & References
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View product citations for antibody "340581" on CiteAb

Development References (20)

  1. Carrel S, Salvi S, Rafti F, Favrot M, Rapin C, Sekaly RP Direct involvement of CD7 (gp40) in activation of TcR γ/δ+ T cells. Eur J Immunol. 1991; 1195-1200. (Biology).
  2. Centers for Disease Control. Update: universal precautions for prevention of transmission of human immunodeficiency virus, hepatitis B virus, and other bloodborne pathogens in healthcare settings. MMWR. 1988; 37:377-388. (Biology).
  3. Clinical and Laboratory Standards Institute. 2005. (Biology).
  4. Foon KA, Todd RF. Immunologic classification of leukemia and lymphoma.. Blood. 1986; 68(1):1-31. (Biology). View Reference
  5. Grümayer ER, Griesinger F, Hummell DS, Brunning RD, Kersey JH. Identification of novel B-lineage cells in human fetal bone marrow that coexpress CD7. Blood. 1991; 77:64-68. (Biology).
  6. Lam GK, Liao HX, Xue Y, et al. Expression of the CD7 ligand K-12 in human thymic epithelial cells: regulation by IFN-γ. J Clin Immunol. 2005; 25:41-49. (Biology).
  7. Lazarovits AI, Karsh J. Decreased expression of CD7 occurs in rheumatoid arthritis. Clin Exp Immunol. 1988; 72:470-475. (Biology).
  8. Lazarovits AI, White MJ, Karsh J. CD7– T cells in rheumatoid arthritis. Arthritis Rheum. 1992; 35:615-624. (Biology).
  9. Link M, Warnke R, Finlay J, et al. A single monoclonal antibody identifies T-cell lineage of childhood lymphoid malignancies. Blood. 1983; 62:722-728. (Biology).
  10. Lyman SD, Escobar S, Rousseau AM, Armstrong A, Fanslow WC. Identification of CD7 as a cognate of the human K12 (SECTM1) protein. J Biol Chem. 2000; 275:3431-3437. (Biology).
  11. Pace KE, Hahn HP, Pang M, Nguyen JT, Baum LG. CD7 delivers a pro-apoptotic signal during galectin-1-induced T cell death. J Immunol. 2000; 165:2331-2334. (Biology).
  12. Palker TJ, Scearce RM, Hensley LL, Ho W, Haynes BF. Comparison of the CD7 (3A1) group of T cell workshop antibodies. In: Reinherz EL, Haynes BF, Nadler LM, Bernstein ID, ed. Leukocyte Typing II. Human T Lymphocytes. New York, NY: Springer-Verlag; 1986:303-313.
  13. Picker LJ, Weiss LM, Medeiros LJ, Wood GS, Warnke RA. Immunophenotypic criteria for the diagnosis of non-Hodgkin's lymphoma.. Am J Pathol. 1987; 128(1):181-201. (Biology). View Reference
  14. Rabinowich H, Lin WC, Herberman RB, Whiteside TL. Signaling via CD7 molecules on human NK cells. Induction of tyrosine phosphorylation and β 1 integrin-mediated adhesion to fibronectin. J Immunol. 1994; 153:3504-3513. (Biology).
  15. Rabinowich H, Pricop L, Herberman RB, Whiteside TL. Expression and function of CD7 molecule on human natural killer cells. J Immunol. 1994; 152(2):517-526. (Biology). View Reference
  16. Reiter C. Knapp W, Dörken B, Gilks WR, et al, ed. Leucocyte Typing IV: White Cell Differentiation Antigens. New York, NY: Oxford University Press; 1989:341-342.
  17. Weiss LM, Crabtree GS, Rouse RV, Warnke RA. Morphologic and immunologic characterization of 50 peripheral T-cell lymphomas. Am J Pathol. 1985; 118:316-324. (Biology).
  18. Weiss LM, Wood GS, Warnke RA. Immunophenotypic differences between dermatopathic lymphadenopathy and lymph node involvement in mycosis fungoides. Am J Pathol. 1985; 120:179-185. (Biology).
  19. Williams AF, Barclay AN. The immunoglobulin superfamily—domains for cell surface recognition. Ann Rev Immunol. 1988; 6:381-405. (Biology).
  20. Wood GS, Abel EA, Hoppe RT, Warnke RA. Leu-8 and Leu-9 antigen phenotypes: immunologic criteria for the distinction of mycosis fungoides from cutaneous inflammation. J Am Acad Dermatol. 1986; 14:1006-1013. (Biology).
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340581 Rev. 1

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