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CD1a PE
Regulatory Status Legend
Any use of products other than the permitted use without the express written authorization of Becton, Dickinson and Company is strictly prohibited.
Preparation And Storage
Vials should be stored at 2° to 8°C. Conjugated forms should not be frozen and should be protected from prolonged exposure to light. Each reagent is stable for the period shown on the bottle label when stored as directed.
The CD1a antibody, clone SK9,1 is derived from hybridization of NS-1 mouse myeloma cells with spleen cells from CD-1 mice immunized with human thymocytes. The CD1a antibody recognizes a 49-kilodalton (kDa) type I transmembrane glycoprotein that associates non-covalently with β2-microglobulin.
Development References (8)
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Boumsell L, Amiot M, Raynal B, Gay-Bellile V, Caillou B, Bernard A. Epitope groups of CD1 molecules. In: Reinherz EL. Ellis L. Reinherz .. et al., ed. Leukocyte typing II. New York: Springer-Verlag; 1986:289-302.
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Centers for Disease Control. Update: universal precautions for prevention of transmission of human immunodeficiency virus, hepatitis B virus, and other bloodborne pathogens in healthcare settings. MMWR. 1988; 37:377-388. (Biology).
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Clinical and Laboratory Standards Institute. 2005. (Biology).
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Dalloul AH, Patry C, Salamero J, Canque B, Grassi F, Schmitt C. Functional and phenotypic analysis of thymic CD34+ CD1a- progenitor-derived dendritic cells: predominance of CD1a- differentiation pathway. J Immunol. 1999; 162:5821-5828. (Biology).
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Ito T, Inaba M, Inaba K, et al. A CD1a+/CD11c+ subset of human blood dendritic cells is a direct precursor of Langerhans cells.. J Immunol. 1999; 163(3):1409-19. (Biology). View Reference
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Martin LH, Calabi F, Lefebvre FA, Bilsland CA, Milstein C. Structure and expression of the human thymocyte antigens CD1a, CD1b, and CD1c.. Proc Natl Acad Sci USA. 1987; 84(24):9189-93. (Biology). View Reference
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Wood GS, Burns BF, Dorfman RF, Warnke RA. The immunohistology of non-T cells in the acquired immunodeficiency syndrome.. Am J Pathol. 1985; 120(3):371-9. (Biology). View Reference
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Wood GS, Warner NL, Warnke RA. Anti–Leu-3/T4 antibodies react with cells of monocyte/macrophage and Langerhans lineage. J Immunol. 1983; 131(1):212-216. (Biology). View Reference
Please refer to Support Documents for Quality Certificates
Global - Refer to manufacturer's instructions for use and related User Manuals and Technical data sheets before using this products as described
Comparisons, where applicable, are made against older BD Technology, manual methods or are general performance claims. Comparisons are not made against non-BD technologies, unless otherwise noted.