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CD21 V450
Product Details
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BD Horizon™
CR2; Complement receptor type 2; C3DR; EBV-R; Epstein-Barr virus receptor
Human
Mouse IgG1, κ
Flow cytometry
13 μg/mL
5 μL
IV B98
1380
ASR


658170 Rev. 1
Antibody Details
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B-ly4

The CD21 antibody, clone B-ly4, is derived from the hybridization of mouse myeloma cells with spleen cells from immunized mice.

The CD21 antibody specifically binds to a 145-kilodalton (kDa) glycosylated type I integral membrane protein. The CD21 antigen is also known as complement receptor type 2 (CR2), C3d receptor, and Epstein-Barr virus receptor (EBV-R).

658170 Rev. 1
Format Details
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V450
BD Horizon™ V450 Dye is part of the BD Horizon™ violet family of dyes. This is a small organic fluorochrome with an excitation maximum (Ex Max) at 405-nm and an emission maximum (Em Max) at 450-nm. BD Horizon™ V450, driven by BD innovation, is designed to be excited by the violet laser (405 nm) and detected using an optical filter centered near 450-nm (e.g., a 450/50-nm bandpass filter). The dye can be excited by the UV (355-nm) laser resulting in cross-laser excitation and spillover. Please ensure that your instrument’s configurations (lasers and optical filters) are appropriate for this dye.
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V450
Violet 405 nm
405 nm
450 nm
658170 Rev.1
Citations & References
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View product citations for antibody "658170" on CiteAb

Development References (11)

  1. Centers for Disease Control. Update: universal precautions for prevention of transmission of human immunodeficiency virus, hepatitis B virus, and other bloodborne pathogens in healthcare settings. MMWR. 1988; 37:377-388. (Biology).
  2. Cherukuri A, Shoham T, Sohn HW, et al. The tetraspanin CD81 is necessary for partitioning of coligated CD19/CD21-B cell antigen receptor complexes into signaling-active lipid rafts. J Immunol. 2004; 172:370-380. (Biology).
  3. Clinical and Laboratory Standards Institute. 2005. (Biology).
  4. Dörken B, Möller P, Pezzutto A, Schwartz-Albiez R, Moldenhauer G. KnappW, Dörken B, Gilks WR, et al, ed. Leucocyte Typing IV: White Cell Differentiation Antigens. New York,NY: Oxford University Press; 1989:46-48.
  5. Fearon DT, Carroll MC. Regulation of B lymphocyte responses to foreign and self-antigens by the CD19/CD21 complex. Annu Rev Immunol. 2000; 18:393-422. (Biology).
  6. Fingeroth JD, Weis JJ, Tedder TF, Strominger JL, Biro PA, Fearon DT. Epstein-Barr virus receptor of human B lymphocytes is the C3d receptor CR2. Proc Natl Acad Sci USA. 1984; 81:4510-4514. (Biology).
  7. Mongini PK, Jackson AE, Tolani S, Fattah RJ, Inman JK. Role of complement-binding CD21/CD19/CD81 in enhancing human B cell protection from Fas-mediated apoptosis. J Immunol. 2003; 171:5244-5254. (Biology).
  8. Petrasch S, Schmitz J, Perez-Alvarez C, Brittinger G. Knapp W, Dörken B, Gilks WR, et al, ed. Leucocyte Typing IV: White Cell Differentiation Antigens. New York, NY: Oxford University Press; 1989:185-187.
  9. Timens W, Boes A, Poppema S. Human marginal zone B cells are not an activated B cell subset: strong expression of CD21 as a putative mediator for rapid B cell activation. Eur J Immunol. 1989; 19:2163-2166. (Biology).
  10. Weis JJ, Tedder TF, Fearon DT. Identification of a 145,000 Mr membrane protein as the C3d receptor (CR2) of human B lymphocytes. Proc Natl Acad Sci USA. 1984; 81:881-885. (Biology).
  11. Zola H, Swart B, Nicholson I, Voss E. Leukocyte and Stromal Cell Molecules: The CD Markers. 2007. (Biology).
View All (11) View Less
658170 Rev. 1

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Analyte Specific Reagent. Analytical and performance characteristics are not established.

Analyte Specific Reagent. Analytical and performance characteristics are not established.

 

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