



Preparation And Storage
Product Notices
- Please refer to www.bdbiosciences.com/us/s/resources for technical protocols.
- Since applications vary, each investigator should titrate the reagent to obtain optimal results.
- Please refer to http://regdocs.bd.com to access safety data sheets (SDS).
- An isotype control should be used at the same concentration as the antibody of interest.
Companion Products






The AM22.1 monoclonal antibody specifically recognizes mouse Interleukin-22 (IL-22) and crossreacts with human IL-22. IL-22 is a member of the IL-10 cytokine family. IL-22 is expressed by some activated T cell subsets including Th17-, Th22- and Th1-like T cells, lymphoid tissue inducer (LTi) cells, as well as some natural killer (NK) cells and innate lymphoid cell (ILC) subsets. IL-22 binds to a heteromeric cell surface IL-22 receptor complex that is comprised of IL-22R1 and IL-10Rβ chains. When IL-22 ligand-bound, this receptor transduces JAK-STAT signaling (eg, phosphorylation of Stat3 at Y705) intracellularly. IL-22 acts on epithelial cells of the skin and mucosal tissues and plays a major role in mediating innate antimicrobial responses by inducing the expression of various mediators including antimicrobial proteins and chemokines. It also plays a roles in wound healing and maintaining epithelial integrity. IL-22 can also act on hepatocytes to stimulate increased acute-phase protein production. Aberrant overexpression of IL-22 can result in certain inflammatory disorders including psoriasis.
Development References (6)
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Disson O, Blériot C, Jacob JM, et al. Peyer's patch myeloid cells infection by Listeria signals through gp38(+) stromal cells and locks intestinal villus invasion. J Exp Med. 2018; 215(11):2936-2954. (Clone-specific: In vivo exacerbation, Neutralization). View Reference
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Pineda MA, Rodgers DT, Al-Riyami L, Harnett W, Harnett MM. ES-62 protects against collagen-induced arthritis by resetting interleukin-22 toward resolution of inflammation in the joints. Arthritis Rheumatol. 2014; 66(6):1492-503. (Clone-specific). View Reference
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Reynders, A., N. Yessaad, et al. Identity, regulation and in vivo function of gut NKp46+RORgammat+ and NKp46+RORgammat- lymphoid cells. EMBO J. 2011; 30:2934-2947. (Biology). View Reference
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Ronchi, F., C. Basso, et al. Experimental priming of encephalitogenic Th1/Th17 cells requires pertussis toxin-driven IL-1beta production by myeloid cells. Nature Commun. 2016; 7:11541. (Biology).
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Sabat R, Ouyang W, Wolk K. Therapeutic opportunities of the IL-22-IL-22R1 system.. Nat Rev Drug Discov. 2014; 13(1):21-38. (Biology). View Reference
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Van Belle AB, de Heusch M, Lemaire MM, et al. IL-22 is required for imiquimod-induced psoriasiform skin inflammation in mice.. J Immunol. 2012; 188(1):462-9. (Clone-specific: Blocking, Functional assay, In vivo exacerbation, Neutralization). View Reference
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Global - Refer to manufacturer's instructions for use and related User Manuals and Technical data sheets before using this products as described
Comparisons, where applicable, are made against older BD Technology, manual methods or are general performance claims. Comparisons are not made against non-BD technologies, unless otherwise noted.
For Research Use Only. Not for use in diagnostic or therapeutic procedures.