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Regulatory Status Legend
Any use of products other than the permitted use without the express written authorization of Becton, Dickinson and Company is strictly prohibited.
Preparation And Storage
Product Notices
- Since applications vary, each investigator should titrate the reagent to obtain optimal results.
- Please refer to www.bdbiosciences.com/us/s/resources for technical protocols.
Companion Products
The WT.3 monoclonal antibody specifically recognizes the 95-100 kDa β2 subunit (CD18), which is found on the majority of leukocytes as a heterodimer with any of the three distinct CD11 α integrin subunits (CD11a or αL, CD11b or αM, CD11c or αX) to form, respectively, LFA-1, Mac-1, and gp150, 95. The function-blocking activity of WT.3 antibody has been determined in several in vitro assays measuring the binding of LFA-1 (αLβ2 integrin) to ICAM-1 (CD54). It has also been reported that WT.3 mAb inhibits leukocyte infiltration in an in vivo system.
Development References (2)
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Tamatani T, Kotani M, Miyasaka M. Characterization of the rat leukocyte integrin, CD11/CD18, by the use of LFA-1 subunit-specific monoclonal antibodies. Eur J Immunol. 1991; 21(3):627-633. (Immunogen: Blocking, Immunoprecipitation). View Reference
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Yamazaki T, Seko Y, Tamatani T, et al. Expression of intercellular adhesion molecule-1 in rat heart with ischemia/reperfusion and limitation of infarct size by treatment with antibodies against cell adhesion molecules. Am J Pathol. 1993; 143(2):410-418. (Clone-specific: Blocking, Immunohistochemistry). View Reference
Please refer to Support Documents for Quality Certificates
Global - Refer to manufacturer's instructions for use and related User Manuals and Technical data sheets before using this products as described
Comparisons, where applicable, are made against older BD Technology, manual methods or are general performance claims. Comparisons are not made against non-BD technologies, unless otherwise noted.
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
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