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Overview

BD® Small Batch Reagents are preformulated, ready-to-use and leverage BD Horizon™ Dri Technology, which reduces variability and eliminates manual pipetting. Our performance-optimized multicolor panels demonstrate consistent use in a variety of clinical research trials and applications. BD® Small Batch Reagents are backed by innovation, based on consensus guidelines, informed by customer voice and collaborations, and supported by high-impact publications.

 

The reagents include BD Horizon™ Dri Panels and Reagents:

 

  • TBNK + CD20 Panel
  • Monoset panel
  • Memory T-cell panel
  • Treg panel
  • Tumor and tissue dissociation reagent (TTDR)
 
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TBNK + CD20 Panel

The BD Horizon™ Dri TBNK + CD20 Multicolor Panel is optimized for immune monitoring research

The panel was designed for clinical research based on key feedback from Mass General Hospital and Harvard Medical School. The addition of CD20 to standard TBNK analysis expands the utility of a very common test. This tube has been used in research and clinical trials, from monitoring immune responses to CD20 depletion therapies.

 

The panel:

  • Characterizes T, B and NK cells
  • Provides absolute counts when paired with BD Trucount™ Tubes
  • Offers standardization with the all-in-one dried format, reducing variability
  • Eliminates manual pipetting, increasing efficiency
  • Is flexible with open channels for liquid drop-ins
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Panel Composition

Format

Specificity

Clone

FITC

CD3

SK7

PE

CD16/56

B73.1/NCAM16.2

PerCP-Cy5.5

CD45

2D1

PE-Cy7

CD4

SK3

APC

CD19

SJ25C1

APC-Cy7

CD8

SK1

V450

CD20

L27

Monoset panel

The BD Horizon™ Dri Monoset Panel is optimized for immunotherapy research and clinical research trials

The panel was designed based on published consensus guidelines to identify and characterize classical, intermediate and nonclassical subsets of monocytes in humans. These levels are quantitated both by absolute number and frequency of each subset. This quantitative value-add is key as it enables standardization of your data across multiple studies. Applications for this tube in research and clinical research trials include but are not limited to cardiology, sepsis, atherosclerosis and as predictive biomarkers for immuno-oncology.

 

The panel:

  • Provides standardized quantification (via ABC* units) when paired with BD Quantibrite™ Beads
  • Offers an analysis template with gating strategy for BD FACSuite™ Research Application
  • Reduces variability with the all-in-one dried format and offers standardization
  • Eliminates manual pipetting, increasing efficiency
  • Is flexible with open channels for liquid drop-ins

*Antibody bound per cell

 

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Panel Composition

Format

Specificity

Clone

FITC

CD16

3G8

PE

HLA-DR

L243

PerCP

CD14

MP9

APC

CD192(CCR2)

LS132.1D9

 

Memory T-cell panel

The BD Horizon™ Memory T-Cell Panel is optimized for cell therapy research and immune system research

This 7-color panel is performance-optimized for use in clinical research and cell therapy applications. The tube contains a dried, pre-aliquoted multicolor cocktail comprising markers that are well-established and widely used for the characterization of CD4 and CD8 naïve and memory T-cell subsets. The identification and characterization of these T-cell subsets are critical in a variety of clinical research applications, including immunity studies, vaccine research and various T-cell therapies.

 

The panel:

  • Characterizes naïve, effector, central and stem cell memory T-cell subsets
  • Offers an analysis template with gating strategy for BD FACSuite™ Research Application
  • Reduces variability with the all-in-one dried format and is standardized
  • Eliminates manual pipetting, increasing efficiency
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Panel Composition

Format

Specificity

Clone

FITC

CD197

150503

PE-Cy7

CD95

DX2

APC-R700

CD27

M-T271

APC-H7

CD3

SK7

V450

CD4

SK3

V500C

CD8

SK1

BV605

CD45RA

HI100

 

Treg panel

The BD Horizon™ Treg Panel is optimized for cell therapy research and immune system research

This 7-color panel is performance-optimized for use in clinical research and cell therapy applications. The tube contains a dried, pre-aliquoted multicolor cocktail comprising markers used for the characterization of FoxP3+ naïve, transitional and effector Treg subsets. Applications for this panel in research and clinical research trials include but are not limited to autoimmunity studies, transplant studies, tumor microenvironment studies and infection.

 

The panel:

  • Offers an analysis template with gating strategy for BD FACSuite™ Research Application
  • Reduces variability with the all-in-one dried format and is standardized
  • Eliminates manual pipetting, increasing efficiency
  • Is flexible with open channels for liquid drop-ins

 

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Panel Composition : Tube 1

Format

Specificity

Clone

BB515

CD25

2A3

 PerCP-Cy5.5

CD4

Sk3

PE-Cy7

CD45RA

L48

APC

CD161

DX12

APC-R700

CD127

HIL-7R-M21

Panel Composition : Tube 2

Format

Specificity

Clone

PE

FoxP3

236A/E7

TTDR

The BD Horizon™ Tumor and Tissue Dissociation Reagent (TTDR) is optimized for tumor microenvironment research

 

The BD Horizon™ TTDR Reagent was designed for gentle and effective dissociation of tumors and tissue for single-cell studies. It is optimized to maximize cell yields, while minimizing cell death and epitope/antigen damage.

 

The reagent:

  • Maximizes cell yields during dissociation while minimizing cell death, epitope/antigen damage
  • Dissociates a variety of tumor types to enable and empower single-cell studies
  • Maintains the heterogeneity and diversity of your samples
 
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PERFORMANCE

BD Horizon™ Dri Reagents can be used to characterize various immune subtypes and dissociate solid tumors into single cells

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References

  1. Snowden E, Porter W, Hahn F, et al. Immunophenotyping and transcriptomic outcomes in PDX-derived TNBC tissue. Mol Cancer Res. 2017;15(4):429-438. doi: 10.1158/1541-7786.MCR-16-0286-T

  2. Sen M, Hahn F, Black TA, et al. Flow based single cell analysis of the immune landscape distinguishes Barrett's esophagus from adjacent normal tissue. Oncotarget. 2019;10(38):3592-3604. doi: 10.18632/oncotarget.26911

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