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      Purified Mouse Anti-Human CD95
      Product Details
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      BD Pharmingen™
      Fas/APO-1
      Human (QC Testing)
      Mouse IgM, κ
      Flow cytometry (Routinely Tested), Fluorescence microscopy, Functional assay (Tested During Development)
      0.5 mg/ml
      AB_393542
      Aqueous buffered solution containing no preservative.
      RUO


      Preparation And Storage

      The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography. This preparation contains no preservatives, thus it should be handled under aseptic conditions. Store undiluted at 4°C.
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      Product Notices

      1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
      2. Please refer to www.bdbiosciences.com/us/s/resources for technical protocols.
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      550042 Rev. 4
      Antibody Details
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      EOS9.1

      Reacts with a 45 kD type I membrane molecule also known as APO-1, or Fas antigen. CD95 belongs to the tumor necrosis factor receptor (TNF-R) family of  proteins and is expressed on various cells, including activated T cells and B cells.  The interaction of CD95, Fas antigen, with Fas ligand is one of the many mechanisms that lead to apoptosis or programmed cell death. The interaction of CD95 expressing target cells with Fas ligand on cytotoxic T cells induces an apoptotic signal leading to target cell death. It has been reported that apoptosis is the mechanism used by the immune system in clonal deletion of self-reactive T cells during embryological development.

      550042 Rev. 4
      Format Details
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      Purified
      Tissue culture supernatant is purified by either protein A/G or affinity purification methods. Both methods yield antibody in solution that is free of most other soluble proteins, lipids, etc. This format provides pure antibody that is suitable for a number of downstream applications including: secondary labeling for flow cytometry or microscopy, ELISA, Western blot, etc.
      Purified
      550042 Rev.4
      Citations & References
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      View product citations for antibody "550042" on CiteAb

      Development References (4)

      1. Kishimoto T. Tadamitsu Kishimoto .. et al., ed. Leucocyte typing VI : white cell differentiation antigens : proceedings of the sixth international workshop and conference held in Kobe, Japan, 10-14 November 1996. New York: Garland Pub.; 1997.
      2. Krammer PH, Dhein J, Walczak H. The role of APO-1-mediated apoptosis in the immune system. Immunol Rev. 1994; (142):175-191. (Biology). View Reference
      3. Nagata S, Golstein P. The Fas death factor. Science. 1995; 267(5203):1449-1456. (Biology). View Reference
      4. Rouvier E, Luciani MF, Golstein P. Fas involvement in Ca(2+)-independent T cell-mediated cytotoxicity. J Exp Med. 1993; 177(1):195-200. (Biology). View Reference
      View All (4) View Less
      550042 Rev. 4

      Please refer to Support Documents for Quality Certificates

       

      Global - Refer to manufacturer's instructions for use and related User Manuals and Technical data sheets before using this products as described

       

      Comparisons, where applicable, are made against older BD Technology, manual methods or are general performance claims.  Comparisons are not made against non-BD technologies, unless otherwise noted.

      For Research Use Only. Not for use in diagnostic or therapeutic procedures.