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The Role of Immune Checkpoint Receptors in Cancer Immunity


The human immune system fights not only external pathogens but also clears internal abnormalities like dying and cancer cells. 

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High-Throughput and High-Dimensional Single-Cell Analysis of Antigen-Specific CD8+ T Cells


T cells play a vital role in immunology by fighting invading pathogens, destroying tumor cells and orchestrating vaccine response. 

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Computational Sorting With HyperFinder, FlowJo™ Software and BD FACSDiva™ Software


The use of machine learning tools like tSNE, UMAP, CITRUS and CellCNN for the analysis of flow cytometry data may result in the discovery of novel cell types with a distinct pattern of surface markers.

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Intracellular Flow Cytometry Analysis Reveals the Involvement of Prostaglandin in the Expansion of Regulatory Hematopoietic Cells in Type 1 Diabetes


The transplant of Haematopoetic Stem and Progenitor cells (HSPC) has been employed in the treatment of haematological malignancies. 

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Analysing Pediatric Immune Response to SARS-CoV -2 Using Flow Cytometry


The COVID-19 pandemic has impacted every country in the world. In adults, 10-20% of the patients develop severe or life-threatening disease.  

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A New 16-Color Flow Cytometry Panel Protocol for the Functional Phenotyping of Circulating Human Cytotoxic
T Cells and NK Cells


Building a panel for the intracellular staining of immune cells could pose several challenges. A protocol published recently in Cell Press STAR Protocols takes these into account and provides a detailed workflow for efficiently phenotyping circulating human cytotoxic T cells and NK cells. 

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Using Single-Cell Multiomics to Identify a Novel Arthritis-Associated Osteoclast Precursor Macrophages


The authors of this article (Hasegawa, et.al, Nat.Immun 2019) have studied the formation of osteoclasts, which play a crucial role in arthritic bone erosion.

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CLL Phenotyping with BD Rhapsody™ Targeted Panels and BD® AbSeq Assays

 

Chronic Lymphoid Leukemia (CLL), the most common form of leukemia in adults, is often characterised by progressive accumulation of incompetent lymphocytes in blood and bone marrow.

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Computational Sorting With HyperFinder, FlowJo™ Software and BD FACSDiva™ Software

 

The use of machine learning tools like tSNE, UMAP, CITRUS and CellCNN for the analysis of flow cytometry data may result in the discovery of novel cell types with a distinct pattern of surface markers.

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Intracellular Flow Cytometry Analysis Reveals the Involvement of Prostaglandin in the Expansion of Regulatory Hematopoietic Cells in Type 1 Diabetes

 

The transplant of Haematopoetic Stem and Progenitor cells (HSPC) has been employed in the treatment of haematological malignancies. However, studies have shown that HSPCs also possess immunoregulatory properties, making them potentially attractive alternatives to immunosuppressive drugs for the treatment of  autoimmune diseases.

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Analysing Pediatric Immune Response to SARS-CoV -2 Using Flow Cytometry


The COVID-19 pandemic has impacted every country in the world. In adults, 10-20% of the patients develop severe or life-threatening disease. However, in children, most patients display only minor symptoms and so their contributions to spreading the SARS-CoV-2 virus is unclear. 

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BD Joins Consortium to Accelerate Technology Development and Lower the Costs in Cell and Gene Therapy Manufacturing


Wouldn’t it be wonderful if we could reach a point in medical history where disease can be cured without drugs? 

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AbSeq Protocol Using the Nano-Well Cartridge-Based Rhapsody Platform to Generate Protein and Transcript Expression Data on the Single-Cell Level


The BD™ AbSeq oligonucleotide-conjugated antibodies, when incorporated into a single-cell mRNA-sequencing experiment, can yield combined transcript and protein expression data.

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Bifidobacteria-Mediated Immune System Imprinting Early In Life


There is mounting evidence to suggest that during the first 3 months of life, the infant gut microbiome is crucial for immune development. Specialised microbes in the infant gut that rely on breast milk for nutrients play a key role in immune-microbe interactions.

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Single-Cell Genomic Approaches for Developing the Next Generation of Immunotherapies

 

In recent times, developments in genomics, proteomics and single-cell technologies, coupled with advances in allied areas like computing and antibody engineering have enabled significant progress in drug development.

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High-Dimensional Flow Cytometry in COVID-19

 

The rapid spread of COVID-19 infections all over the world and the need to develop a vaccine has necessitated the understanding of the adaptive immune response to the SARS-CoV-2 virus. 

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High-Parameter Flow Cytometry for Deep Immune Profiling of COVID-19 Patients

 

The SARS-CoV-2 virus infection presents a range of clinical manifestations, ranging from mild or no symptoms to moderate to severe respiratory illnesses, such as ARDS (acute respiratory-distress syndrome) and multiorgan failure, to death. The innate immune defense mounted by the body involves pattern recognition receptors (PAR), which activate an array of transcription factors through a signal transduction pathway, ultimately resulting in the secretion of different interferons and chemokines.

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Immunotyping of Natural Killer (NK) Cells in COVID-19 Patients Using High-Parameter Flow Cytometry

SARS-CoV-2 infection elicits a spectrum of immune responses, activating both the innate and adaptive immune systems. Whether these immune responses are targeted and controlled or misdirected and uncontrolled could determine the outcome of the disease. Recent studies using deep immunoprofiling have indicated that the nature of immune responses can also determine the severity of the disease.

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