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FITC Mouse Anti-Human CD62L
Regulatory Status Legend
Any use of products other than the permitted use without the express written authorization of Becton, Dickinson and Company is strictly prohibited.
Preparation And Storage
Store vials at 2°C–8°C. Conjugated forms should not be frozen. Protect from exposure to light. Each reagent is stable until the expiration date shown on the bottle label when stored as directed.
CD62L, clone SK11, is derived from hybridization of mouse NS-1 myeloma cells with spleen cells from BALB/c mice immunized with peripheral blood T lymphocytes. The CD62L antigen, Mr 80 kilodaltons (kd), is the leucocyte endothelial cellular adhesion molecule (LECAM). The CD62L antigen belongs to the selectin family of cell adhesion molecules. The CD62L molecule is the human homologue of the murine lymph node homing receptor, MEL 14.
Development References (14)
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Bevilacqua M, Butcher E, Furie B, et al. Selectins: a family of adhesion receptors. Cell. 1991; 67:233. (Biology).
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Camerini D, James SP, Stamenkovic I, Seed B. Leu-8/TQ1 is the human equivalent of the Mel-14 lymph node homing receptor. Nature. 1989; 342(6245):78-82. (Biology). View Reference
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Carbone A, Manconi R, Poletti A, Gloghini A, Paoli DE, Volpe R. Expression of Leu-8 surface antigen in B-cell lymphomas: correlation with other B-cell markers. J Pathol. 1988; 154:133. (Biology).
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Centers for Disease Control. Update: universal precautions for prevention of transmission of human immunodeficiency virus, hepatitis B virus, and other bloodborne pathogens in healthcare settings. MMWR. 1988; 37:377-388. (Biology).
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Clinical and Laboratory Standards Institute. 2005. (Biology).
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Diacovo T, Springer TA. CD62L (L-selectin) cluster report. In: Schlossman SF. Stuart F. Schlossman .. et al., ed. Leucocyte typing V : white cell differentiation antigens : proceedings of the fifth international workshop and conference held in Boston, USA, 3-7 November, 1993. Oxford: Oxford University Press; 1995:1503-1504.
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Gatenby PA, Kansas GS, Xian CY, Evans RL, Engleman EG. Dissection of immunoregulatory subpopulations of T lymphocytes within the helper and suppressor sublineages in man. J Immunol. 1982; 129(5):1997-2000. (Biology). View Reference
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Kanof ME, James SP. Leu-8 antigen expression is diminished during cell activation but does not correlate with effector function of activated T lymphocytes. J Immunol. 1988; 140:3701-3706. (Biology).
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Kanof ME, Strober W, James SP. Induction of CD4 suppressor T cells with anti-Leu-8 antibody. J Immunol. 1987; 139(1):49-54. (Biology). View Reference
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Kansas GS, Wood GS, Engleman EG. Maturational and functional diversity of human B lymphocytes delineated with Anti-Leu-8. J Immunol. 1985; 134:3003-3006. (Biology).
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Kansas GS, Wood GS, Fishwild DM, Engleman EG. Functional characterization of human T lymphocyte subsets distinguished by monoclonal anti-leu-8. J Immunol. 1985; 134(5):2995-3002. (Biology). View Reference
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Lanier LL, Engleman EG, Gatenby P, Babcock GF, Warner NL, Herzenberg LA. Correlation of functional properties of human lymphoid cell subsets and surface marker phenotypes using multiparameter analysis and flow cytometry. Immun Rev. 1983; 74:143. (Biology).
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Lanier LL, Loken MR. Human lymphocyte subpopulations identified by using three-color immunofluorescence and flow cytometry analysis: correlation of Leu-2, Leu-3, Leu-7, Leu-8, and Leu-11 cell surface antigen expression. J Immunol. 1984; 132:151. (Biology).
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Michie SA, Garcia CF, Strickler JG, Dailey MO, Rouse RV, Warnke RA. Expression of the Leu-8 antigen by B-cell lymphomas. Am J Clin Pathol. 1987; 88(4):486-490. (Biology). View Reference
Please refer to Support Documents for Quality Certificates
Global - Refer to manufacturer's instructions for use and related User Manuals and Technical data sheets before using this products as described
Comparisons, where applicable, are made against older BD Technology, manual methods or are general performance claims. Comparisons are not made against non-BD technologies, unless otherwise noted.
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
Although not required, these products are manufactured in accordance with Good Manufacturing Practices.