Preparation And Storage
Product Notices
- Since applications vary, each investigator should titrate the reagent to obtain optimal results.
- Please refer to www.bdbiosciences.com/us/s/resources for technical protocols.
- Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
- Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Companion Products
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Drugs that selectively attack dividing cells are often used in cancer therapy. However, small cell populations do not die, but develop resistance to a variety of toxic drugs. Multidrug resistance is achieved by gene amplification of specific membrane-bound transport ATPases that shuttle the drugs out of cells. Some multidrug-resistant cancer cells express a protein of 110 kDa named LRP (Lung Resistance-related Protein). LRP expression might be an indicator of prognosis after chemotherapy in acute myeloid leukemia and ovarian carcinoma. The LRP gene encodes a protein of 896 amino acids with significant homology to the major vault protein from Dictyostelium discoideum. Although ubiquitously expressed, LRP is most abundant in epithelial cells.
Development References (4)
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Kickhoefer VA, Rome LH. The sequence of a cDNA encoding the major vault protein from Rattus norvegicus. Gene. 1994; 151(1-2):257-260. (Biology). View Reference
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List AF, Spier CS, Grogan TM. Overexpression of the major vault transporter protein lung-resistance protein predicts treatment outcome in acute myeloid leukemia. Blood. 1996; 87(6):2464-2469. (Biology). View Reference
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Rybarova S, Batekova M, Hodorova I. Immunohistochemical detection of LRP protein in the normal human lung. Bratisl Lek Listy. 2002; 102(2):66-72. (Clone-specific: Immunohistochemistry). View Reference
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Scheffer GL, Wijngaard PL, Flens MJ. The drug resistance-related protein LRP is the human major vault protein. Nat Med. 1995; 1(6):578-582. (Biology). View Reference
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Global - Refer to manufacturer's instructions for use and related User Manuals and Technical data sheets before using this products as described
Comparisons, where applicable, are made against older BD Technology, manual methods or are general performance claims. Comparisons are not made against non-BD technologies, unless otherwise noted.
For Research Use Only. Not for use in diagnostic or therapeutic procedures.