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BD Pharmingen™ Alexa Fluor® 647 Rat Anti-Human IL-31RA
Clone V1-1110 (RUO)







































Regulatory Status Legend
Any use of products other than the permitted use without the express written authorization of Becton, Dickinson and Company is strictly prohibited.
Preparation And Storage
The V1-1110 monoclonal antibody specifically recognizes the Interleukin-31 Receptor subunit alpha (IL-31R alpha, IL-31RA, or IL-31Rα) which is also known as gp130-like Monocyte Receptor (GLMR or hGLM-R) or Cytokine receptor-like 3 (CRL3). IL-31RA is a type I transmembrane glycoprotein that is encoded by IL31RA and is classified as a type I cytokine receptor. IL-31RA associates with the Oncostatin M Receptor (OSMR) to form a heterodimeric signaling receptor for IL-31. Through this heterodimeric receptor, IL-31 can elicit intracellular JAK/STAT (including activated Stat3, Stat5, or Stat1), RAS/ERK and PI3K/AKT signal transduction pathways. IL-31RA is variably expressed by monocytes, dendritic cells, keratinocytes, and epithelial cells. IL-31RA and OSMR are inducibly expressed by cells within the myelomonocytic lineage such as monocytes treated with IFN-γ and bacterial lipopolysaccharide (LPS). IL-31RA signaling plays important roles in both innate and adaptive immunity and inflammation in tissues that are in close contact with the environment including the skin, lung, and intestines.
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Comparisons, where applicable, are made against older BD Technology, manual methods or are general performance claims. Comparisons are not made against non-BD technologies, unless otherwise noted.
For Research Use Only. Not for use in diagnostic or therapeutic procedures.