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Alexa Fluor® 647 Rat Anti-Human IL-31RA
566351
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EA (1 Each)
50 µg
Product Details
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BD Pharmingen™
IL31RA; IL-31R-alpha; GLMR; GLM-R; hGLM-R; CRL3
Human (QC Testing)
Rat LEW, also known as Lewis IgG2a, κ
Flow cytometry (Routinely Tested)
0.2 mg/ml
AB_2739705
Aqueous buffered solution containing ≤0.09% sodium azide.
RUO


Preparation And Storage

Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography. The antibody was conjugated to Alexa Fluor® 647 under optimum conditions, and unreacted Alexa Fluor® 647 was removed.

Data Sheets

566351 Rev. 1
Antibody Details
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V1-1110

The V1-1110 monoclonal antibody specifically recognizes the Interleukin-31 Receptor subunit alpha (IL-31R alpha, IL-31RA, or IL-31Rα) which is also known as gp130-like Monocyte Receptor (GLMR or hGLM-R) or Cytokine receptor-like 3 (CRL3). IL-31RA is a type I transmembrane glycoprotein that is encoded by IL31RA and is classified as a type I cytokine receptor. IL-31RA associates with the Oncostatin M Receptor (OSMR) to form a heterodimeric signaling receptor for IL-31. Through this heterodimeric receptor, IL-31 can elicit intracellular JAK/STAT (including activated Stat3, Stat5, or Stat1), RAS/ERK and PI3K/AKT signal transduction pathways. IL-31RA is variably expressed by monocytes, dendritic cells, keratinocytes, and epithelial cells. IL-31RA and OSMR are inducibly expressed by cells within the myelomonocytic lineage such as monocytes treated with IFN-γ and bacterial lipopolysaccharide (LPS). IL-31RA signaling plays important roles in both innate and adaptive immunity and inflammation in tissues that are in close contact with the environment including the skin, lung, and intestines.

566351 Rev. 1
Format Details
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Alexa Fluor™ 647
Alexa Fluor™ 647 Dye is part of the BD red family of dyes. This is a small organic fluorochrome with an excitation maximum (Ex Max) at 653-nm and an emission maximum (Em Max) at 669-nm. Alexa Fluor 647 is designed to be excited by the Red laser (627-640 nm) and detected using an optical filter centered near 520-nm (e.g., a 660/20 nm bandpass filter). Please ensure that your instrument’s configurations (lasers and optical filters) are appropriate for this dye.
Alexa Fluor™ 647
653 nm
669 nm
566351 Rev.1
Citations & References
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No Citations Found

No Citations Are Available for this Product

566351 Rev. 1

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For Research Use Only. Not for use in diagnostic or therapeutic procedures.